Effects of live attenuated polio vaccine on the immunogenicity of live attenuated rotavirus vaccine

Q4 Immunology and Microbiology 中华微生物学和免疫学杂志 Pub Date : 2019-12-31 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.12.007

Yueyue Liu, Yan Liu, Jialiang Du, Qingchuan Yu, Jiamei Gao, R. Zhao

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Abstract

Objective To evaluate whether simultaneous vaccination with live attenuated polio vaccine affects the immunogenicity of live attenuated rotavirus (RV) vaccine. Methods Rotarix produced by GlaxoSmithKline was used as the research object. Two doses of Rotarix were orally administered on day 0 and month 1, and oral live attenuated polio vaccine (OPV) was administered on day 0, month 1 and month 2 according to the national vaccination plan. Healthy infants aged 6 to 16 weeks were randomly divided into two groups: interval vaccination group (Rotarix and OPV were vaccinated on different days) and simultaneous vaccination group (Rotarix and OPV were vaccinated on the same day). Serum samples were collected on day 0, month 2 and month 12, and serum RV-IgA was measured by enzyme linked immunosorbent assay. Statistical analysis was performed to evaluate whether there were statistical differences in the seroconversion rate and level distribution of RV-IgA between the two groups. Results The seroconversion rate of serum RV-IgA in month 2 was 73.84% in the interval vaccination and 63.95% in the simultaneous vaccination group, and the difference between them was statistically significant (P 0.05). Compared with the simultaneous vaccination group, the seroconversion rate and GMC of serum RV-IgA in month 12 were higher in the interval vaccination group, and the differences were statistically significant (P<0.05). Conclusions Simultaneous vaccination with live attenuated polio vaccine would affect the immune response of live attenuated rotavirus vaccine, especially the maintenance of RV-IgA antibody level. Key words: Poliovirus; Rotavirus; Vaccine; Immunogenicity

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脊髓灰质炎减毒活疫苗对轮状病毒减毒活疫苗免疫原性的影响

目的评价脊髓灰质炎减毒活疫苗同时接种对轮状病毒减毒活苗免疫原性的影响。方法以葛兰素史克公司生产的Rotarix为研究对象。根据国家疫苗接种计划，Rotarix在第0天和第1个月口服两剂，脊髓灰质炎减毒活疫苗（OPV）在第0、第1和第2个月口服。将6-16周的健康婴儿随机分为两组：间隔接种组（Rotarix和OPV在不同日期接种）和同时接种组（Rotrix和OPV在同一天接种）。在第0天、第2个月和第12个月采集血清样本，并通过酶联免疫吸附测定法测量血清RV IgA。进行统计分析以评估两组之间RV IgA的血清转化率和水平分布是否存在统计学差异。结果2个月血清RV IgA转阴率间隔接种组为73.84%，同时接种组为63.95%，差异有统计学意义（P＜0.05），结论同时接种脊髓灰质炎减毒活疫苗会影响轮状病毒减毒活苗的免疫应答，尤其是RV IgA抗体水平的维持。关键词：脊髓灰质炎病毒；轮状病毒；疫苗；免疫原性

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.