Catalytic derivatization of 2-Aminobenzo[d]thiazole for observing antibacterial activity and in silico analysis

Abstract

2-Aminobenzo[d]thiazoles have been converted to corresponding acetanilides and 2-hydroxy compounds for observing antibacterial activities. The acetylation was done by direct use of acetic acid, whereas the corresponding 2-hydroxy derivative was synthesized following various reaction conditions with or without a catalyst for observing the associated yield and ease of the reaction. In this study, the reaction yield was found to be between 20% and 86%. The synthesized acetanilides and the 2-hydroxy compounds were screened for antibacterial activity against various common pathogenic gram-positive and gram-negative organisms. Encouraging antimicrobial potential was noted from these small molecules. Finally, the compounds were taken for in silico analysis to observe the possible orientations in the binding site of the alanine racemase enzyme of Enterococcus faecalis.