Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034

IF 1.4 4区生物学 Q4 GENETICS & HEREDITY Genetics research Pub Date : 2022-03-31 DOI:10.1155/2022/4901090

Maricela Aceves-Ramírez, Y. Valle, Fidel Casillas-Muñoz, Diana Emilia Martínez-Fernández, Brenda Parra-Reyna, Víctor Arturo López-Moreno, H. E. Flores-Salinas, Emmanuel Valdés-Alvarado, J. Muñóz-Valle, Texali C Garcia-Garduño, J. Padilla-Gutiérrez

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引用次数: 2

Abstract

Apolipoprotein B (APOB) is associated with the development of atherosclerosis and consequently in the acute coronary syndrome (ACS) physiopathology. Single number variants (SNVs) in apolipoprotein B gene (APOB) influence over the susceptibility for this syndrome. The aim of this study was to determine the impact of the rs1469513, rs673548, rs676210, and rs1042034 SNVs and serum levels of APOB in the risk of ACS in a population from western Mexico. We included 300 patients in the group of cases (ACSG) and 300 individuals in the control group (CG). APOB levels were evaluated by immunonephelometry, and SNVs were genotyped with TaqMan probes. We found significant allelic and genotypic differences between groups for rs673548 and rs676210 (OR = 1.33, p=0.030, OR = 2.69, p < 0.001) and rs1042034 (OR = 0.50, p=0.037) SNVs. We found a risk haplotype TAGT (OR: 2.14, IC 1.50–3.04, p < 0.001). Our findings support a significant risk association between rs673548 and rs676210 variants for ACS; meanwhile, rs1042034 could be considered protective factor in a western Mexican population. Also, in this population, haplotype TAGT may confer 2.14 times a higher risk. APOB serum levels were compared by genotype variants in both groups without any significant statistical difference.

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墨西哥急性冠脉综合征人群APOB基因和载脂蛋白B血清水平分析:与单核苷酸变异rs1469513、rs673548、rs676210和rs1042034的关系

载脂蛋白B（APOB）与动脉粥样硬化的发展有关，因此与急性冠状动脉综合征（ACS）的病理生理学有关。载脂蛋白B基因（APOB）的单数变异（SNVs）对该综合征易感性的影响。本研究的目的是确定rs1469513、rs673548、rs676210和rs1042034 SNV以及血清APOB水平对墨西哥西部人群ACS风险的影响。我们将300名患者纳入病例组（ACSG），将300名个体纳入对照组（CG）。通过免疫浊度法评估APOB水平，并用TaqMan探针对SNVs进行基因分型。我们发现rs673548和rs676210在各组之间存在显著的等位基因和基因型差异（OR = 1.33，p=0.030，或 = 2.69，p＜0.001）和rs1042034（OR = 0.50，p=0.037）SNV。我们发现了一个风险单倍型TAGT（OR:2.14，IC1.50-3.04，p<0.001）。我们的研究结果支持rs673548和rs676210变异株之间存在显著的ACS风险关联；同时，rs1042034可以被认为是墨西哥西部人口的保护因素。此外，在该人群中，单倍型TAGT可能会带来2.14倍的高风险。通过基因型变异比较两组的APOB血清水平，没有任何显著的统计学差异。

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来源期刊

Genetics research 生物-遗传学

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Genetics Research is a key forum for original research on all aspects of human and animal genetics, reporting key findings on genomes, genes, mutations and molecular interactions, extending out to developmental, evolutionary, and population genetics as well as ethical, legal and social aspects. Our aim is to lead to a better understanding of genetic processes in health and disease. The journal focuses on the use of new technologies, such as next generation sequencing together with bioinformatics analysis, to produce increasingly detailed views of how genes function in tissues and how these genes perform, individually or collectively, in normal development and disease aetiology. The journal publishes original work, review articles, short papers, computational studies, and novel methods and techniques in research covering humans and well-established genetic organisms. Key subject areas include medical genetics, genomics, human evolutionary and population genetics, bioinformatics, genetics of complex traits, molecular and developmental genetics, Evo-Devo, quantitative and statistical genetics, behavioural genetics and environmental genetics. The breadth and quality of research make the journal an invaluable resource for medical geneticists, molecular biologists, bioinformaticians and researchers involved in genetic basis of diseases, evolutionary and developmental studies.