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{"title":"Using INTERSPIA to Explore the Dynamics of Protein-Protein Interactions Among Multiple Species","authors":"Daehong Kwon, Daehwan Lee, Juyeon Kim, Jongin Lee, Mikang Sim, Jaebum Kim","doi":"10.1002/cpbi.88","DOIUrl":null,"url":null,"abstract":"<p>INTER-Species Protein Interaction Analysis (INTERSPIA) is a web application for identifying diverse patterns of protein-protein interactions (PPIs) in different species. Given a set of proteins of interest to the user, INTERSPIA first discovers additional proteins that are functionally associated with the input proteins as well as different or common patterns of PPIs among the proteins in multiple species through a server-side pipeline. Second, it visualizes the dynamics of PPIs in multiple species via an easy-to-use web interface. This article contains a basic protocol describing how to visualize diverse patterns of PPIs of input proteins in multiple species, and how to use them for functional analysis in the web interface. INTERSPIA is freely available at http://bioinfo.konkuk.ac.kr/INTERSPIA/. © 2019 by John Wiley & Sons, Inc.</p><p><b>Basic Protocol</b>: Running INTERSPIA using a list of input proteins</p>","PeriodicalId":10958,"journal":{"name":"Current protocols in bioinformatics","volume":"68 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/cpbi.88","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current protocols in bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cpbi.88","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
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Abstract
INTER-Species Protein Interaction Analysis (INTERSPIA) is a web application for identifying diverse patterns of protein-protein interactions (PPIs) in different species. Given a set of proteins of interest to the user, INTERSPIA first discovers additional proteins that are functionally associated with the input proteins as well as different or common patterns of PPIs among the proteins in multiple species through a server-side pipeline. Second, it visualizes the dynamics of PPIs in multiple species via an easy-to-use web interface. This article contains a basic protocol describing how to visualize diverse patterns of PPIs of input proteins in multiple species, and how to use them for functional analysis in the web interface. INTERSPIA is freely available at http://bioinfo.konkuk.ac.kr/INTERSPIA/. © 2019 by John Wiley & Sons, Inc.
Basic Protocol : Running INTERSPIA using a list of input proteins
利用INTERSPIA探索多物种之间蛋白质-蛋白质相互作用的动力学
物种间蛋白质相互作用分析(INTERSPIA)是一个用于识别不同物种中蛋白质相互作用(PPIs)的不同模式的web应用程序。给定用户感兴趣的一组蛋白质，INTERSPIA首先通过服务器端管道发现与输入蛋白质在功能上相关的其他蛋白质，以及多个物种中蛋白质中不同或共同的ppi模式。其次，它通过一个易于使用的网络界面可视化多个物种的ppi动态。这篇文章包含了一个基本的协议，描述了如何在多个物种中可视化不同的输入蛋白的ppi模式，以及如何在web界面中使用它们进行功能分析。INTERSPIA可在http://bioinfo.konkuk.ac.kr/INTERSPIA/免费获得。©2019 by John Wiley &基本方案:使用输入蛋白列表运行INTERSPIA
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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