Expression pattern and prognostic significance of baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) in breast cancer: A comprehensive analysis

IF 2 Q3 ONCOLOGY Advances in cancer biology - metastasis Pub Date : 2022-07-01 DOI:10.1016/j.adcanc.2022.100037

Umar Mehraj, Shariqa Aisha, Shazia Sofi, Manzoor Ahmad Mir

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引用次数: 14

Abstract

Background

Baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, member of the inhibitor of apoptosis (IAP), is a multitasking protein and among the top 100 deregulated genes in breast cancer patients. It negatively regulates apoptosis of tumor cells by inducing gene expression of anti-apoptotic proteins, promoting tumor cell proliferation, and modulates response to chemotherapeutics.

Objective

The main objective of the study was to analyze the expression pattern, prognostic significance and functional role of BIRC5 in breast cancer (BC).

Methods

In the present study, we utilized a bioinformatic approach, to analyze the expression pattern and prognostic significance of BIRC5 in BC and explore the interactions of BIRC5 in promoting breast tumorigenicity.

Results

BIRC5 mRNA levels were augmented in breast carcinoma & over-expression of BIRC5 was found associated with poor overall survival (OS) and relapse-free survival (RFS). The KEGG pathway and gene ontology analysis of BIRC5 indicate that BIRC5 is highly enriched in mitotic pathways and cancer pathways. The PPI and correlation analysis further revealed that BIRC5 showed high with oncogenic proteins. Moreover, BIRC5 showed high correlation with infiltration of myeloid derived suppressor cells (MDSCs) in the breast tumor stroma.

Conclusions

Cumulatively, this study signifies that BIRC5 promotes tumor progression, & targeting BIRC5 in combination with conventional therapies will significantly enhance the response of BC patients to therapy.

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杆状病毒细胞凋亡重复抑制因子5 (BIRC5)在乳腺癌中的表达模式及预后意义

baculoviral inhibitor of apoptosis repeat-containing 5或BIRC5是凋亡抑制剂(inhibitor of apoptosis, IAP)的成员，是一种多任务蛋白，是乳腺癌患者中前100个解除调控的基因之一。它通过诱导抗凋亡蛋白基因表达负向调控肿瘤细胞凋亡，促进肿瘤细胞增殖，调节对化疗药物的反应。目的分析BIRC5在乳腺癌(BC)中的表达规律、预后意义及功能作用。方法应用生物信息学方法，分析BIRC5在乳腺癌中的表达模式及预后意义，探讨BIRC5在促进乳腺致瘤性中的相互作用。结果birc5 mRNA水平在乳腺癌中升高;发现BIRC5过表达与总生存期(OS)和无复发生存期(RFS)较差相关。对BIRC5的KEGG通路和基因本体论分析表明，BIRC5在有丝分裂通路和肿瘤通路中高度富集。PPI和相关分析进一步显示BIRC5具有较高的致癌蛋白。此外，BIRC5与乳腺肿瘤基质中髓源性抑制细胞(myeloid derived suppressor cells, MDSCs)的浸润高度相关。综上所述，本研究提示BIRC5促进肿瘤进展;靶向BIRC5联合常规治疗将显著提高BC患者对治疗的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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