{"title":"Molecular biology of urothelial carcinoma","authors":"P. Liang, T. Chan, Y. Shiue, Chien-Fen Li","doi":"10.4103/JCRP.JCRP_1_21","DOIUrl":null,"url":null,"abstract":"Objective: Urothelial carcinoma (UC) is a common malignant tumor worldwide. Extensive genomic data analysis revealed that UC has a complex molecular character. From the perspective of cancer hallmarks reviewed the molecular biology participated in the tumorigenesis of UC. Data Sources: We inspected the results of multiple studies of UC focusing on the hallmarks of cancer. Results: UC has distinctive molecular pathways involved in sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, promotion of replicative immortality, induction of angiogenesis, activation of invasion and metastasis, genome instability and mutation, tumor-promoting inflammation, reprogramming of energy metabolism, and evasion of immune destruction. Conclusion: From the perspective of the hallmark of cancer, we revealed the many-sided biological behavior of UC.","PeriodicalId":31219,"journal":{"name":"Journal of Cancer Research and Practice","volume":"8 1","pages":"1 - 8"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cancer Research and Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/JCRP.JCRP_1_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Objective: Urothelial carcinoma (UC) is a common malignant tumor worldwide. Extensive genomic data analysis revealed that UC has a complex molecular character. From the perspective of cancer hallmarks reviewed the molecular biology participated in the tumorigenesis of UC. Data Sources: We inspected the results of multiple studies of UC focusing on the hallmarks of cancer. Results: UC has distinctive molecular pathways involved in sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, promotion of replicative immortality, induction of angiogenesis, activation of invasion and metastasis, genome instability and mutation, tumor-promoting inflammation, reprogramming of energy metabolism, and evasion of immune destruction. Conclusion: From the perspective of the hallmark of cancer, we revealed the many-sided biological behavior of UC.
期刊介绍：
JCRP aims to provide an exchange forum for the cancer researchers and practitioners to publish their timely findings in oncologic disciplines. The scope of the Journal covers basic, translational and clinical research, Cancer Biology, Cancer Immunotherapy, Hemato-oncology, Digestive cancer, Urinary tumor, Germ cell tumor, Breast cancer, Lung cancer, Head and Neck Cancer in a vast range of cancer related topics. The Journal also seeks to enhance and advance the cancer care standards in order to provide cancer patients the best care during the treatments.
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