Establishment of Withdrawal Period after Oral Administration of Lincomycin and Colistin Combination in Broiler Chicken

Abstract

Received: Revised: Accepted: Published online: August 22, 2019 October 18, 2019 October 25, 2019 November 06, 2019 The combination of lincomycin and colistin is widely used in poultry either for the prevention and treatment of bacterial infection or as additive. However, the presence of antimicrobial residues in food of animal origin is considered as threat to human health. Therefore, this study determined the withdrawal time (WT) by analyzing the residual concentration in tissues to overcome this problem. A combination product of lincomycin and colistin was administered to chickens. Antibiotic residues in edible tissues at different time-intervals were quantified using ELISA and chromatographic methods, and WT was determined. Antibiotics residues were high in the liver and kidney but were lower than the MRL on day 1 and rapidly decreased from day 3. The WT in the kidney was calculated as 2.95 days and is rounded off to 3 days. This study suggested the withdrawal time of 3 days as a precautionary principle for public health. ©2019 PVJ. All rights reserved