Advances in research of nephrotoxicity and toxic antagonism of ochratoxin A

IF 3.3 4区 医学 Q2 TOXICOLOGY Toxin Reviews Pub Date : 2017-01-02 DOI:10.1080/15569543.2016.1243560
T. Zhao, X. L. Shen, Wenying Chen, Xin-Di Liao, Jieyeqi Yang, Yan Wang, Yan Zou, Cuilan Fang
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引用次数: 25

Abstract

Abstract Ochratoxin A (OTA) is a widespread mycotoxin that naturally takes place in various human foodstuffs, such as cereals, cereal products, fruits, vegetables, meat, eggs, dairy products, dried products, wine and even the infant formula. Thus, the generation of serious harm to human health is inevitable. Among a variety of toxicological effects of OTA, nephrotoxicity is the most prominent. Until present, the review focusing on the nephrotoxicity of OTA was absent. Therefore, the advances in research of nephrotoxicity, nephrotoxicity mechanisms and toxic antagonism of OTA were reviewed in the present paper.
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赭曲霉毒素A的肾毒性及毒性拮抗研究进展
摘要赭毒素A(OTA)是一种广泛存在的真菌毒素,天然存在于各种人类食品中,如谷物、谷物制品、水果、蔬菜、肉、蛋、乳制品、干产品、葡萄酒甚至婴儿配方奶粉。因此,对人类健康产生严重危害是不可避免的。在OTA的多种毒理学作用中,肾毒性最为突出。到目前为止,还没有关于OTA肾毒性的综述。因此,本文就OTA的肾毒性、肾毒性机制及毒性拮抗作用等方面的研究进展作一综述。
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来源期刊
Toxin Reviews
Toxin Reviews 医学-毒理学
CiteScore
6.80
自引率
0.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.
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