Response surface methodology for optimisation of glycyrrhizic acid extraction from Glycyrrhiza glabra in the aqueous two-phase system

IF 0.9 Q4 ENGINEERING, CHEMICAL Indian Chemical Engineer Pub Date : 2022-06-16 DOI:10.1080/00194506.2022.2085194
Kavita J. Lanjekar, V. Rathod
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Abstract

ABSTRACT Glycyrrhizic acid (GA) is a natural sweetener obtained from Licorice (Glycyrrhiza glabra) and has numerous biological activities. In the present study, partitioning of GA in the polyethylene glycol (PEG)-salt aqueous two-phase system (ATPS) was optimised using the central composite design of response surface methodology (RSM). Effects of different operational parameters, such as salt concentration, pH, molecular weight of PEG, and concentration were studied to recover GA. The RSM predicted optimised conditions comprised 15.65% (w/v) of PEG 4000, 19.69% (w/v) of Sodium citrate and pH 8.0, yielding 28.39 mg/g GA. The close resemblance of the predicted and experimental yield of GA outlined the successful validation of the response model. In addition, the ATPS method offered lower energy, process time, cost economics and solvent consumption over conventional Soxhlet extraction. GRAPHICAL ABSTRACT
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响应面法优化双水相体系中光甘草中甘草酸的提取
摘要甘草酸是从甘草中提取的一种天然甜味剂,具有多种生物活性。在本研究中,使用响应面法的中心复合设计优化了GA在聚乙二醇(PEG)-盐水两相体系(ATPS)中的分配。研究了不同操作参数(如盐浓度、pH、PEG分子量和浓度)对GA回收的影响。RSM预测的最佳条件包括15.65%(w/v)的PEG 4000、19.69%(w/v的柠檬酸钠和pH 8.0,得到28.39 mg/g GA。GA的预测产量和实验产量非常相似,说明了响应模型的成功验证。此外,与传统的索氏提取相比,ATPS方法提供了更低的能量、工艺时间、成本经济性和溶剂消耗。图形摘要
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来源期刊
Indian Chemical Engineer
Indian Chemical Engineer ENGINEERING, CHEMICAL-
CiteScore
3.00
自引率
6.70%
发文量
33
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