Clinical characteristics and treatment outcomes of germ cell tumor in Jordan: A tertiary center experience.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-03 eCollection Date: 2023-01-01 DOI:10.1080/2090598X.2022.2163473

A El-Achkar, H Alasadi, J El-Asmar, A Armache, R Abu-Hijlih, F Abu-Hijle, A Al-Ibraheem, J Khzouz, S Salah, M Shahait

{"title":"Clinical characteristics and treatment outcomes of germ cell tumor in Jordan: A tertiary center experience.","authors":"A El-Achkar, H Alasadi, J El-Asmar, A Armache, R Abu-Hijlih, F Abu-Hijle, A Al-Ibraheem, J Khzouz, S Salah, M Shahait","doi":"10.1080/2090598X.2022.2163473","DOIUrl":null,"url":null,"abstract":"Objective: In the Middle East, there is a paucity of data regarding germ cell tumor characteristics and treatment outcomes. Herein, we aim to present the largest series in Jordan reporting our cancer center experience managing GCT.Methods: Between 2010 and 2020, a total of 241 patients with a pathological diagnosis of GCT were treated at our cancer center. Demographic, epidemiologic, and pathological data were retrospectively collected. In addition, survival and relapse outcomes based on tumor stage and adjuvant treatment were collected.Results: A total of 241 patients were diagnosed with GCT, of whom 108 (44.8%) had seminoma and 133 (55.2%) had non-seminoma tumors (NSGCT). Median age (interquartile range) at diagnosis was 31 years (25-36). Patients with seminoma (68.5%) had pT1 disease post orchiectomy, while only 37.5% of patients with NSGCT had pT1 on final pathology. Elevated tumor markers such as beta-human chorionic gonadotropin were present in 10% of seminomas. Following radical orchiectomy and staging, 88 (36.5%) went for active surveillance while 153 patients (63.5%) received adjuvant treatment. With regard to pathology slides read outside, rereading by our genitourinary pathologist yielded a discrepancy on GCT type in 41 (19.3%) out of 212 patients. The median follow-up was 36 (24-48) months. Twenty-two patients relapsed after an average follow-up time of 39 months. The 5-year overall survival for stage I, II, and III was 98%, 94%, and 87%, respectively, and 3-year recurrence-free survival for stage I, II, and III was 94.8%, 78%, and 67%, respectively.Conclusion: Our data on testicular GCT including demographic, histological, and treatment outcomes were comparable to that of developed countries. In light of the pathology discrepancy rate revealed in our study, authors recommend a second review by expert genitourinary pathologists to ensure proper classification and management of GCT.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"233-239"},"PeriodicalIF":17.7000,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10763583/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/2090598X.2022.2163473","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: In the Middle East, there is a paucity of data regarding germ cell tumor characteristics and treatment outcomes. Herein, we aim to present the largest series in Jordan reporting our cancer center experience managing GCT.

Methods: Between 2010 and 2020, a total of 241 patients with a pathological diagnosis of GCT were treated at our cancer center. Demographic, epidemiologic, and pathological data were retrospectively collected. In addition, survival and relapse outcomes based on tumor stage and adjuvant treatment were collected.

Results: A total of 241 patients were diagnosed with GCT, of whom 108 (44.8%) had seminoma and 133 (55.2%) had non-seminoma tumors (NSGCT). Median age (interquartile range) at diagnosis was 31 years (25-36). Patients with seminoma (68.5%) had pT1 disease post orchiectomy, while only 37.5% of patients with NSGCT had pT1 on final pathology. Elevated tumor markers such as beta-human chorionic gonadotropin were present in 10% of seminomas. Following radical orchiectomy and staging, 88 (36.5%) went for active surveillance while 153 patients (63.5%) received adjuvant treatment. With regard to pathology slides read outside, rereading by our genitourinary pathologist yielded a discrepancy on GCT type in 41 (19.3%) out of 212 patients. The median follow-up was 36 (24-48) months. Twenty-two patients relapsed after an average follow-up time of 39 months. The 5-year overall survival for stage I, II, and III was 98%, 94%, and 87%, respectively, and 3-year recurrence-free survival for stage I, II, and III was 94.8%, 78%, and 67%, respectively.

Conclusion: Our data on testicular GCT including demographic, histological, and treatment outcomes were comparable to that of developed countries. In light of the pathology discrepancy rate revealed in our study, authors recommend a second review by expert genitourinary pathologists to ensure proper classification and management of GCT.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

约旦生殖细胞肿瘤的临床特征和治疗结果：三级中心经验

目的：在中东地区，有关生殖细胞肿瘤特征和治疗效果的数据非常少。在此，我们旨在介绍约旦最大的生殖细胞瘤系列，报告我们癌症中心治疗生殖细胞瘤的经验：方法：2010 年至 2020 年期间，共有 241 名病理诊断为 GCT 的患者在我们的癌症中心接受了治疗。我们回顾性地收集了人口统计学、流行病学和病理学数据。此外，还收集了基于肿瘤分期和辅助治疗的生存和复发结果：结果：共有241名患者被确诊为GCT，其中108人（44.8%）为精原细胞瘤，133人（55.2%）为非精原细胞瘤（NSGCT）。确诊时的中位年龄（四分位数间距）为 31 岁（25-36 岁）。睾丸切除术后，精原细胞瘤患者（68.5%）的病理结果为pT1，而在NSGCT患者中，只有37.5%的患者最终病理结果为pT1。10%的精原细胞瘤患者肿瘤标志物（如β-人绒毛膜促性腺激素）升高。在进行根治性睾丸切除术和分期后，88 名患者（36.5%）接受了积极监测，153 名患者（63.5%）接受了辅助治疗。关于外院病理切片，泌尿生殖系统病理学家重读后发现，212 例患者中有 41 例（19.3%）的 GCT 类型存在差异。中位随访时间为 36（24-48）个月。22例患者在平均随访39个月后复发。I、II和III期患者的5年总生存率分别为98%、94%和87%，I、II和III期患者的3年无复发生存率分别为94.8%、78%和67%：结论：我们关于睾丸GCT的数据，包括人口统计学、组织学和治疗结果，与发达国家的数据相当。鉴于我们的研究中发现的病理差异率，作者建议由泌尿生殖系统病理专家进行第二次复查，以确保对 GCT 进行正确的分类和管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

期刊最新文献

Manifestations of Boron-Alkali Metal and Boron-Alkaline-Earth Metal Romances Issue Publication Information Issue Editorial Masthead Mapping and Rewiring Biology via Proximity Induction Thermodynamic Principles Behind Mechanisms and Reactivities: Hydrogen Atom Abstraction and Related Radical Reactions.