Portable Ultraviolet-C Chambers for Inactivation of SARS-CoV-2.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-03-18 eCollection Date: 2021-01-01 DOI:10.6028/jres.126.056

Shelby Claytor, Roger Campbell, Ashton Hattori, Eric Brown, Christopher Hollis, Max Schureck, Howard Atchley, John Stone, Michael Grady, Benjamin Yang, T Robert Harris

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Abstract

The goal of this project was to create and optimize the performance of portable chambers for reliable ultraviolet (UV) disinfection of personal protective equipment (PPE) and enable its safe reuse. During unforeseen times of high demand for PPE, such as during the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), single-use PPE supply can be quickly depleted. UV radiation has been shown to disinfect materials with high efficacy. This paper reports the design and construction of two 280 nm ultraviolet-C (UV-C) disinfection chambers in the form of portable chambers with 46 cm × 46 cm × 46 cm interior dimensions, one using light-emitting diodes and the other using mercury vapor lamps. This paper summarizes and presents a review of SARS-CoV-2 UV deactivation research during 2020 to 2021. Additionally, this paper discusses efforts to increase the uniformity and overall intensity of the UV-C radiation within the chambers through the installation of a UV-reflective, porous polytetrafluoroethylene (PTFE) material. A calculator prototype was additionally designed to calculate the reduction of SARS-CoV-2 as a result of UV-C disinfection, and the prototype code is presented. The paper describes the selection of UV-C radiation sources for the chambers and the chambers' mechanical and electrical design, PTFE installation, testing, and safety considerations.

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便携式SARS-CoV-2灭活紫外- c室

该项目的目标是创建和优化便携式消毒室的性能，以便对个人防护设备进行可靠的紫外线消毒，并使其能够安全重复使用。在个人防护用品需求旺盛的不可预见的时期，例如在严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（新冠肺炎）大流行期间，一次性个人防护用品供应可能会迅速耗尽。紫外线辐射已被证明可以对材料进行高效消毒。本文报道了两个280nm紫外线-C（UV-C）消毒室的设计和建造，其形式为内部尺寸为46cm×46cm×46 cm的便携式消毒室，一个使用发光二极管，另一个使用汞蒸气灯。本文总结并回顾了2020年至2021年严重急性呼吸系统综合征冠状病毒2型紫外线失活研究。此外，本文还讨论了通过安装紫外线反射多孔聚四氟乙烯（PTFE）材料来提高室内UV-C辐射的均匀性和总体强度的努力。此外，还设计了一个计算器原型来计算UV-C消毒导致的严重急性呼吸系统综合征冠状病毒2型的减少，并给出了原型代码。本文介绍了紫外线-C辐射源的选择，以及辐射室的机械和电气设计、聚四氟乙烯的安装、测试和安全注意事项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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