Are Adults Over 18 Years of Age with Anaemia More Likely to Develop Chronic Periodontitis Than Adults Without Anaemia? - A Systematic Review and Meta-Analysis.
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Abstract
Aims and objectives: Periodontitis is a chronic disease affecting the supporting tissues of the teeth and exhibits bidirectional relation with systemic diseases. This study aims to determine the association between chronic periodontitis and erythrocyte functional measures: total red blood cells (RBCs), hemoglobin (Hb) concentration, mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC) by systematic review and meta-analysis.
Materials and methods: A systematic search of the electronic databases PUBMED, OVID, Embase, Web on Science, and Google Scholar was undertaken from inception to July 2022. English language studies that evaluated the erythrocyte functional measures in periodontitis and health were selected. Other review reports, letters/opinion articles, studies without a definition of periodontitis, and the concomitant presence of systemic conditions (diabetes, kidney disease, cancer) were excluded. Two reviewers determined full-text eligibility in a blinded process. Meta-Essentials software was used to generate forest plots and to determine heterogeneity and publication bias.
Results: Twenty-six studies involving 1082 patients with chronic periodontitis and 980 healthy controls were analyzed. Pooled results showed lower Hb concentration (Hedges' g = -1.16; 95% confidence intervals [CI], -1.7 to -0.62), RBC counts (Hedges' g = -0.85; 95% CI, -1.31 to -0.38) and packed cell volume (-0.56; 95% CI, -1.02 to -0.11) in patients with chronic periodontitis.
Conclusion: This meta-analysis showed a decreasing trend in the hematological parameters, including hemoglobin concentration, number of erythrocytes, and hematocrit in patients with chronic periodontitis compared to healthy controls.
目的：牙周炎是一种影响牙齿支持组织的慢性疾病，与系统性疾病呈双向关系。本研究旨在通过系统综述和荟萃分析来确定慢性牙周炎与红细胞功能指标之间的关系：总红细胞（RBCs）、血红蛋白（Hb）浓度、平均红细胞体积（MCV）和平均红细胞血红蛋白浓度（MCHC）。材料和方法：从成立到2022年7月，对电子数据库PUBMED、OVID、Embase、Web on Science和Google Scholar进行了系统搜索。选择了评估牙周炎和健康中红细胞功能测量的英语研究。排除了其他综述报告、信函/意见文章、没有牙周炎定义的研究以及伴随的全身性疾病（糖尿病、肾病、癌症）。两名评审员在盲法过程中确定了全文合格性。Meta Essentials软件用于生成森林图，并确定异质性和发表偏倚。结果：分析了26项研究，涉及1082名慢性牙周炎患者和980名健康对照。汇总结果显示，慢性牙周炎患者的Hb浓度（Hedges’g=−1.16；95%置信区间[CI]，−1.7至−0.62）、红细胞计数（Hedges'g=−0.85；95%可信区间，−1.31至−0.38）和堆积细胞体积（−0.56；95%CI，−1.02至−0.11）较低。结论：该荟萃分析显示，与健康对照组相比，慢性牙周炎患者的血液学参数（包括血红蛋白浓度、红细胞数量和红细胞压积）呈下降趋势。
期刊介绍：
It is a journal aimed for research, scientific facts and details covering all specialties of dentistry with a good determination for exploring and sharing the knowledge in the medical and dental fraternity. The scope is therefore huge covering almost all streams of dentistry - starting from original studies, systematic reviews, narrative reviews, very unique case reports. Journal scope is not limited to these subjects and is more wider covering all specialities of dentistry follows: -Preventive and Community dentistry (Dental public health)- Endodontics- Oral and maxillofacial pathology- Oral and maxillofacial radiology- Oral and maxillofacial surgery (also called oral surgery)- Orthodontics and dentofacial orthopedics- Periodontology (also called periodontics)- Pediatric dentistry (also called pedodontics)- Prosthodontics (also called prosthetic dentistry)- Oral medicine- Special needs dentistry (also called special care dentistry)- Oral Biology- Forensic odontology- Geriatric dentistry or Geriodontics- Preventive and Social Medicine (Public health)- Our journal appreciates research articles pertaining with advancement of dentistry, preventive and community dentistry including oral epidemiology, oral health services research, oral health education and promotion, behavioral sciences related to dentistry, dental jurisprudence, ethics and oral health, economics, and quality assessment, recent advances in preventive dentistry and community dentistry.
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