Bacterial Cellulose Loaded with Amoxicillin/ Flucloxacillin: Innovate Tool for Antibacterial Applications

Abstract

applications. Bacterial cellulose (BC) synthesizing Komagataeibacter hansenii S strain was isolated from strawberry, and the 16S rDNA sequence homologies reached 99% with Komagataeibacter hansenii strain LMG 1527 so that the isolate can be identified as Komagataeibacter hansenii S. The isolated strain was selected owing to its high production yield of (5.4±0.6 g/l, dry weight) under optimized culturing conditions. The morphological and physicochemical features of the produced BC were studied by SEM, FTIR, XRD, TG, and mechanical tests. FESEM showed the three-dimensional porous nanofiber structure. FTIR and XRD confirmed the structure of BC. TG revealed the thermal stability of produced BC with good mechanical properties. Amoxicillin/ Flucloxacillin impregnated BC nanofibers exhibited high antibacterial potency against both Gram-positive and Gram-negative bacteria. Physicochemical and mechanical features of BC produced by Komagataeibacter hansenii S indicate its availability to be explored in food packaging, wound dressing, and fuel cell membranes