Synthesis of oligosaccharide fragments of capsular polysaccharide Staphylococcus aureus type 8

Abstract

To enhance our understanding of the activation and conjugation processes, reported herein is the synthesis of oligosaccharides comprising two sequential repeating units of capsular polysaccharide S. aureus serotype 8 (CP8). As in our previous syntheses of staphylococcal oligosaccharides, the potential propagation positions are blocked with methyl groups. While protein conjugates of carbohydrate antigens based on the structure of the S. aureus capsular serotypes have the potential to contribute to a S. aureus vaccine, despite promising preclinical data, efficacy has not been detected in human populations thus far.