The cause of cancer: The unifying theory

Marie-Ange Majérus
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引用次数: 2

Abstract

Nowadays, still, the exact etiology of cancer remains to be uncovered. The understanding that cancer results from uncontrolled proliferation of cells does not provide a solution to curing cancer. Although several irreconciliable theories on the cause of cancer have been proposed, none explain the overall complexity of the disease. Yet, there is the remarkable discovery that the Egg Cell’s Genetic Program (ECGP) has the potentiel to produce cancer. Based on this first and only experimental model created in the mid-20th century where cancer can be observed in statu nascendi, I hypothesized that cancer arises from a cell reprogrammed with the ECGP as a plausible model that brings together all the pieces of the cancer puzzle.

Today, the experimental production of induced Pluripotent Stem Cells (iPSC’s) and their differentiated derivatives, together with their risk of cancer formation validated this theory.

This is of prime importance as it opens a non-existing line of research with high potential for the fight against cancer. We can transpose the knowledge of the ECGP to facilitate the study of a selective treatment for cancer. Instead of basing therapeutic strategies on the fate of cancer cells, we should consider the potential of the ECGP to produce cancer as the key factor to devise an effective therapeutic strategy that selectively targets cancer cells. I then propose a non-toxic metabolic approach to treating cancer which, instead of killing cancer cells, gives them respiration.

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癌症的起因:统一理论
时至今日,癌症的确切病因仍有待发现。癌症是由细胞不受控制的增殖引起的这一认识并没有提供治疗癌症的解决方案。尽管人们提出了一些关于癌症起因的互不相容的理论,但没有一个能解释这种疾病的总体复杂性。然而,有一个显著的发现,卵细胞的遗传程序(ECGP)有产生癌症的潜力。基于第一个也是唯一一个在20世纪中期创建的实验模型,癌症可以在新生状态下观察到,我假设癌症起源于一个细胞与ECGP重新编程,作为一个合理的模型,它汇集了癌症之谜的所有部分。今天,诱导多能干细胞(iPSC)及其分化衍生物的实验生产,以及它们形成癌症的风险,验证了这一理论。这是最重要的,因为它开辟了一条不存在的研究路线,具有很高的抗癌潜力。我们可以利用ECGP的知识来促进癌症选择性治疗的研究。我们不应该将治疗策略建立在癌细胞的命运上,而应该将ECGP产生癌症的潜力作为设计一种选择性靶向癌细胞的有效治疗策略的关键因素。然后,我提出了一种无毒的代谢方法来治疗癌症,这种方法不是杀死癌细胞,而是让它们呼吸。
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来源期刊
Advances in cancer biology - metastasis
Advances in cancer biology - metastasis Cancer Research, Oncology
CiteScore
2.40
自引率
0.00%
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0
审稿时长
103 days
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