{"title":"The cause of cancer: The unifying theory","authors":"Marie-Ange Majérus","doi":"10.1016/j.adcanc.2022.100034","DOIUrl":null,"url":null,"abstract":"<div><p>Nowadays, still, the exact etiology of cancer remains to be uncovered. The understanding that cancer results from uncontrolled proliferation of cells does not provide a solution to curing cancer. Although several irreconciliable theories on the cause of cancer have been proposed, none explain the overall complexity of the disease. Yet, there is the remarkable discovery that the Egg Cell’s Genetic Program (ECGP) has the potentiel to produce cancer. Based on this first and only experimental model created in the mid-20th century where cancer can be observed <em>in statu nascendi</em>, I hypothesized that cancer arises from a cell reprogrammed with the ECGP as a plausible model that brings together all the pieces of the cancer puzzle.</p><p>Today, the experimental production of induced Pluripotent Stem Cells (iPSC’s) and their differentiated derivatives, together with their risk of cancer formation validated this theory.</p><p>This is of prime importance as it opens a non-existing line of research with high potential for the fight against cancer. We can transpose the knowledge of the ECGP to facilitate the study of a selective treatment for cancer. Instead of basing therapeutic strategies on the fate of cancer cells, we should consider the potential of the ECGP to produce cancer as the key factor to devise an effective therapeutic strategy that selectively targets cancer cells. I then propose a non-toxic metabolic approach to treating cancer which, instead of killing cancer cells, gives them respiration.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"4 ","pages":"Article 100034"},"PeriodicalIF":2.0000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000089/pdfft?md5=9967bffb0cd853643a910399d7913884&pid=1-s2.0-S2667394022000089-main.pdf","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in cancer biology - metastasis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667394022000089","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 2
Abstract
Nowadays, still, the exact etiology of cancer remains to be uncovered. The understanding that cancer results from uncontrolled proliferation of cells does not provide a solution to curing cancer. Although several irreconciliable theories on the cause of cancer have been proposed, none explain the overall complexity of the disease. Yet, there is the remarkable discovery that the Egg Cell’s Genetic Program (ECGP) has the potentiel to produce cancer. Based on this first and only experimental model created in the mid-20th century where cancer can be observed in statu nascendi, I hypothesized that cancer arises from a cell reprogrammed with the ECGP as a plausible model that brings together all the pieces of the cancer puzzle.
Today, the experimental production of induced Pluripotent Stem Cells (iPSC’s) and their differentiated derivatives, together with their risk of cancer formation validated this theory.
This is of prime importance as it opens a non-existing line of research with high potential for the fight against cancer. We can transpose the knowledge of the ECGP to facilitate the study of a selective treatment for cancer. Instead of basing therapeutic strategies on the fate of cancer cells, we should consider the potential of the ECGP to produce cancer as the key factor to devise an effective therapeutic strategy that selectively targets cancer cells. I then propose a non-toxic metabolic approach to treating cancer which, instead of killing cancer cells, gives them respiration.