{"title":"Systems biology approaches to interpreting genomic data","authors":"Twan van den Beucken","doi":"10.1016/j.cotox.2019.02.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Technological developments in genome-wide analysis have accelerated the generation of large, complex data sets characterizing human biology at the molecular level. Integration of data from different molecular levels holds great promise for gaining understanding of complex biological systems. Toxicogenomics aims to obtain a comprehensive mechanistic map of </span>cellular processes that drive adverse outcomes. Such an integrated approach relies on combining various genome-wide profiles (DNA, RNA, protein, and metabolite) and linking these to functional endpoints to allow the identification of relevant biological pathways. Here, current strategies for generating multiomic data within the domain of toxicogenomics are highlighted, and current strategies for multiomic data integration are discussed.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"18 ","pages":"Pages 1-7"},"PeriodicalIF":3.6000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.02.004","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202019300026","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 3
Abstract
Technological developments in genome-wide analysis have accelerated the generation of large, complex data sets characterizing human biology at the molecular level. Integration of data from different molecular levels holds great promise for gaining understanding of complex biological systems. Toxicogenomics aims to obtain a comprehensive mechanistic map of cellular processes that drive adverse outcomes. Such an integrated approach relies on combining various genome-wide profiles (DNA, RNA, protein, and metabolite) and linking these to functional endpoints to allow the identification of relevant biological pathways. Here, current strategies for generating multiomic data within the domain of toxicogenomics are highlighted, and current strategies for multiomic data integration are discussed.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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