Evaluating the Effects of Molecular Dynamic And Docking of Abemaciclib, Hymenialdisine, and Indirubin on CDK-2 Inhibition by Simulation Study

M. Asadi-Samani, N. Jamali, Javad Saffari-Chaleshtori, Korosh Ashrafi-Dehkordi
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Abstract

Background & objectives: Cyclin-dependent kinase 2 (CDK-2) is a serine/threonine protein kinase with regulatory activity in the cell cycle. Inhibitors of this protein are the treatment of choice for a variety of cancers by stopping the cell cycle. In this in silico study, the effects of docking and molecular dynamics of Abemaciclib, Hymenialdisine
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Abemaciclib、Hymenialdisine和Indirubin分子动力学及对接对CDK-2抑制作用的模拟研究
背景与目的:细胞周期蛋白依赖性激酶2 (CDK-2)是一种丝氨酸/苏氨酸蛋白激酶,在细胞周期中具有调节活性。这种蛋白质的抑制剂是通过阻止细胞周期来治疗多种癌症的首选。本论文对Abemaciclib、Hymenialdisine的对接效应和分子动力学进行了研究
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