{"title":"Potentiometric determination of Minoxidil in topical use pharmaceutical samples","authors":"R. A. Sousa, É. Cavalheiro","doi":"10.1590/S0100-46702009000200003","DOIUrl":null,"url":null,"abstract":"A potentiometric titration method for the determination of minoxidil based on its re- dox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":"34 1","pages":"23-27"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/S0100-46702009000200003","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ecletica Quimica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/S0100-46702009000200003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Physics and Astronomy","Score":null,"Total":0}
引用次数: 4
Abstract
A potentiometric titration method for the determination of minoxidil based on its re- dox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.
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