Polydeoxyribonucleotide: A promising skin anti-aging agent

Chinese Journal of Plastic and Reconstructive Surgery Pub Date : 2022-12-01 DOI:10.1016/j.cjprs.2022.09.015

Aawrish Khan, Guobao Wang, Feng Zhou, Lunli Gong, Jun Zhang, Lili Qi, Haiyan Cui

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引用次数: 4

Abstract

Polydeoxyribonucleotide (PDRN) consists of DNA fragments with molecular weights ranging from 50 to 1 500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many preclinical and clinical studies have demonstrated the properties of PDRN. These include anti-inflammatory, anti-apoptotic, anti-osteoporotic, anti-melanogenetic, anti-allodynic, anti-osteonecrotic, bone regenerative, tissue damage preventive, anti-ulcerative, and wound healing properties, which are mediated by the activation of the adenosine A_2A receptor and salvage pathways. Moreover, PDRN promotes angiogenesis, cellular activity, collagen synthesis, soft tissue regeneration, and skin priming and revitalization and can be used to treat hyperpigmentation. Therefore, this review assessed the potential use of PDRN as an anti-aging agent for the skin.

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聚脱氧核糖核苷酸：一种很有前途的皮肤抗衰老剂

多脱氧核糖核苷酸(PDRN)由分子量在50 ~ 1 500 kDa之间的DNA片段组成，主要从鲑鱼、鳟鱼和鲑鱼的精子细胞中提取。许多临床前和临床研究已经证明了PDRN的特性。这些包括抗炎、抗凋亡、抗骨质疏松、抗黑素生成、抗异变、抗骨坏死、骨再生、组织损伤预防、抗溃疡和伤口愈合特性，这些特性是由腺苷A2A受体的激活和修复途径介导的。此外，PDRN促进血管生成，细胞活性，胶原合成，软组织再生，皮肤启动和振兴，可用于治疗色素沉着。因此，本综述评估了PDRN作为皮肤抗衰老剂的潜在用途。

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来源期刊

Chinese Journal of Plastic and Reconstructive Surgery Surgery, Otorhinolaryngology and Facial Plastic Surgery, Pathology and Medical Technology, Transplantation

CiteScore

0.40

自引率

0.00%

发文量

115

审稿时长

55 days