A. Bawa-Allah, M. Mashao, T. Nyundu, E. Phukubje, B. G. Nkosi, M. V. Ngema, B. Mlambo, M. Maseko
{"title":"SERUM LIPID PROFILE AND ARTERIAL STIFFNESS IN NON-DIPPERS","authors":"A. Bawa-Allah, M. Mashao, T. Nyundu, E. Phukubje, B. G. Nkosi, M. V. Ngema, B. Mlambo, M. Maseko","doi":"10.11603/ijmmr.2413-6077.2020.1.11014","DOIUrl":null,"url":null,"abstract":"Background. A non-dipping blood pressure profile (NDP) is associated with increased arterial stiffness and other cardiovascular target organ damage. Serum lipid profiles have been shown to be important determinants of arterial stiffness. Objective. The aim of the research was to assess serum lipid profiles and arterial stiffness in non-dippers. Methods. This cross-sectional study was conducted involving 796 (288 males and 508 females) participants of black African origin. A twenty-four-hour ambulatory BP monitoring was done using a Spacelabs 90207 (Spacelabs Inc., Redmond, Washington, USA) monitor. Carotid-Femoral pulse wave velocity measurements were performed using a high fidelity SPC-301 micromanometer (Millar instruments Inc., Houston, TX). Results. Of the 288 males, 140 were classified as non-dippers. Of the 508 females, 273 were classified as non-dippers. In the general population, males had higher triglycerides when compared with females 1.46±0.96 vs 1.13±1.02, p<0.0001. Additionally, dipper males had higher serum TRGL when compared with dipper females 1.32±0.98 vs 1.06±0.58, p = 0.0012. Non-dipper males also had higher serum TRGL when compared with nondipper females 1.61±2.05 vs 1.19±1.14, p=0.0078. Serum HDLc was lower in the non-dipper male group when compared to the non-dipper female group (p=0.008). In both male and female groups, non-dippers had higher CFPWV when compared with dippers; 7.53±3.60 vs 5.74±2.47, p<0.0001 and 6.64±2.52 vs 5.98±2.23, p=0.0021 respectively. However, non-dipper males had significantly higher CFPWV when compared with non-dipper females (7.53±3.60 vs 6.64±2.52, p=0.0031). Conclusions. Therapies targeting a reduction of serum triglycerides levels might be beneficial in improving arterial compliance with or without the presence of non-dipping.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Medicine and Medical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11603/ijmmr.2413-6077.2020.1.11014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background. A non-dipping blood pressure profile (NDP) is associated with increased arterial stiffness and other cardiovascular target organ damage. Serum lipid profiles have been shown to be important determinants of arterial stiffness. Objective. The aim of the research was to assess serum lipid profiles and arterial stiffness in non-dippers. Methods. This cross-sectional study was conducted involving 796 (288 males and 508 females) participants of black African origin. A twenty-four-hour ambulatory BP monitoring was done using a Spacelabs 90207 (Spacelabs Inc., Redmond, Washington, USA) monitor. Carotid-Femoral pulse wave velocity measurements were performed using a high fidelity SPC-301 micromanometer (Millar instruments Inc., Houston, TX). Results. Of the 288 males, 140 were classified as non-dippers. Of the 508 females, 273 were classified as non-dippers. In the general population, males had higher triglycerides when compared with females 1.46±0.96 vs 1.13±1.02, p<0.0001. Additionally, dipper males had higher serum TRGL when compared with dipper females 1.32±0.98 vs 1.06±0.58, p = 0.0012. Non-dipper males also had higher serum TRGL when compared with nondipper females 1.61±2.05 vs 1.19±1.14, p=0.0078. Serum HDLc was lower in the non-dipper male group when compared to the non-dipper female group (p=0.008). In both male and female groups, non-dippers had higher CFPWV when compared with dippers; 7.53±3.60 vs 5.74±2.47, p<0.0001 and 6.64±2.52 vs 5.98±2.23, p=0.0021 respectively. However, non-dipper males had significantly higher CFPWV when compared with non-dipper females (7.53±3.60 vs 6.64±2.52, p=0.0031). Conclusions. Therapies targeting a reduction of serum triglycerides levels might be beneficial in improving arterial compliance with or without the presence of non-dipping.
背景非下降血压曲线(NDP)与动脉硬度增加和其他心血管靶器官损伤有关。血脂谱已被证明是动脉硬化的重要决定因素。客观的这项研究的目的是评估非铲斗患者的血脂状况和动脉硬化。方法。这项横断面研究涉及796名非洲黑人参与者(288名男性和508名女性)。使用Spacelabs 90207(Spacelabs股份有限公司,Redmond,Washington,USA)监测仪进行24小时动态BP监测。使用高保真度SPC-301微压计(Millar instruments股份有限公司,Houston,TX)进行颈动脉-脉搏波速度测量。后果288名男性中,140人被归类为非铲斗类。在508名女性中,273名被归类为非铲斗类。在普通人群中,与女性相比,男性甘油三酯较高,分别为1.46±0.96和1.13±1.02,p<0.0001。此外,与杓鹬雌蛛相比,杓鹬雄蛛的血清TRGL更高,分别为1.32±0.98和1.06±0.58,p=0.0012。与非糖尿病女性相比,非糖尿病男性的血清TRGL也较高,分别为1.61±2.05和1.19±1.14,p=0.0078。与非铲斗型女性组相比,非铲斗型男性组的血清HDLc较低(p=0.008)。在男性和女性组中,与铲斗型相比,非斗型男性组具有较高的CFPWV;7.53±3.60 vs 5.74±2.47,p<0.0001;6.64±2.52 vs 5.98±2.23,p=0.0021。然而,与非铲斗型女性相比,非铲斗型男性的CFPWV显著更高(7.53±3.60 vs 6.64±2.52,p=0.0031)。结论。针对降低血清甘油三酯水平的治疗可能有利于改善动脉顺应性,无论是否存在非浸渍。