MHRT expression during remote ischemic preconditioning in patients with coronary artery disease

Q4 Biochemistry, Genetics and Molecular Biology Biopolymers and Cell Pub Date : 2021-08-31 DOI:10.7124/bc.000a59

M. Khetsuriani, N. O. Ioffe, T. Drevytska, V. O. Niekrasova, V. Dosenko

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Abstract

Aim. This study aimed to access the effect of remote ischemic preconditioning (RIPC) on hemodynamic parameters and expression of lncRNA MHRT in patients with coronary artery disease during isolated coronary artery bypass graft surgery. Methods. The hemodynamic parameters of 29 patients with sham and RIPC procedure were analyzed. RIPC was modu-lated by three cycles of blocking blood flow in the arm for 5 minutes followed by restoring it for another 5 minutes. Expression of MHRT was measured in myocardial tissue and plasma by real-time polymerase chain reaction. Results. Hemodynamic parameters of patients in the RIPC-group had higher (p<0.05) values of cardiac index, systolic blood pressure, diastolic blood pressure, stroke volume index compared to the sham group. Systemic vascular resistance index decreased in RIPC-group. The expression level of MHRT in the myocardium was 2.5 times lower than in the sham group (p<0.05). MHRT expression in plasma fall[s] significantly, by more [than]15 times, (p<0.0001) in the RIPC-group. Conclusions. A decrease in MHRT expression can be a consequence of the protective effect of RIPC and can be used as a cardiac biomarker.

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冠状动脉疾病患者远端缺血预处理过程中MHRT的表达

的目标。本研究旨在探讨远程缺血预处理(remote ischemic preconditioning, RIPC)对冠心病患者在离体冠状动脉搭桥手术中血流动力学参数及lncRNA MHRT表达的影响。方法。对29例假手术和RIPC手术患者的血流动力学参数进行分析。RIPC通过阻断手臂血流3个周期5分钟，然后再恢复5分钟来调节。实时聚合酶链反应检测心肌组织和血浆中MHRT的表达。结果。ripc组患者的心脏指数、收缩压、舒张压、脑卒中容积指数等血流动力学参数均高于sham组(p<0.05)。ripc组全身血管阻力指数下降。心肌组织中MHRT的表达水平比假手术组低2.5倍(p<0.05)。ripc组血浆中MHRT表达明显下降[s]，下降[超过]15倍，(p<0.0001)。结论。MHRT表达的减少可能是RIPC保护作用的结果，可以用作心脏生物标志物。

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来源期刊

Biopolymers and Cell Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

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1.10

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0.00%

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期刊介绍： “Biopolymer and cell” is published since 1985 at the Institute of Molecular Biology and Genetics NAS of Ukraine under the supervision of the National Academy of Sciences of Ukraine. Our journal covers a wide scope of problems related to molecular biology and genetics including structural and functional genomics, transcriptomics, proteomics, bioinformatics, biomedicine, molecular enzymology, molecular virology and immunology, theoretical bases of biotechnology, physics and physical chemistry of proteins and nucleic acids and bioorganic chemistry.