Impairments in Metabolism of Amino Acids—Precursors of Gasotransmitters—in the Premature Birth

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2022-02-14 DOI:10.1134/S1990750822010061

A. A. Mikhelson, T. N. Pogorelova, V. O. Gunko, A. A. Nikashina, N. V. Palieva

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引用次数: 2

Abstract—

The content of amino acids, the sources of gasotransmitters and activities of enzymes involved in their metabolism have been studied in the placenta and amniotic fluid in full-term and complicated by preterm birth. Determination of amino acids was performed using an automatic analyzer and enzyme activities were assayed by means of specific spectrophotometric methods. The development of preterm birth was accompanied by notable changes in metabolism amino acids already in the second trimester of pregnancy. Differently directed correlations were found between the level of amino acids and the activity of the corresponding enzymes. The imbalance of amino acids in the fetoplacental system in preterm birth was accompanied by changes in the production of their low molecular weight derivatives—gasotransmitters (NO, CO, H₂S), playing an important role in the regulation of numerous metabolic processes.

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早产儿中气体递质前体氨基酸代谢的损伤

摘要:本文研究了足月及早产儿胎盘和羊水中氨基酸含量、气递质来源及其代谢酶的活性。用自动分析仪测定氨基酸，用专用分光光度法测定酶活性。早产的发生伴随着妊娠中期代谢氨基酸的显著变化。氨基酸水平与相应酶的活性之间存在不同方向的相关性。早产儿胎儿胎盘系统中氨基酸的失衡伴随着其低分子量衍生物气体递质(NO, CO, H2S)产生的变化，在许多代谢过程的调节中起着重要作用。

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Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

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1.10

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0.00%

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期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.