Neurotransmitter Impairments in the Brain Induced by Acute Combined Intoxication of Rats with Ethanol and Morphine

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2022-02-14 DOI:10.1134/S1990750822010103

I. M. Vialichko, S. V. Lelevich, V. V. Lelevich, E. M. Doroshenko, V. Yu. Smirnov

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Abstract—

The levels of biogenic monoamines and their metabolites have been investigated in the hypothalamus, midbrain, and cerebellum of rats exposed to acute combined intoxication with morphine and ethanol. A single treatment of rats with ethanol and morphine caused neurotransmitter impairments in particular parts of the brain; they depended on the order of morphine and ethanol administration. The combined intoxication with ethanol and morphine led to signs of dopamine utilization only in the hypothalamus, regardless of the order of administration of psychoactive substances (PAS). During alcohol-morphine intoxication in the studied parts of the brain there was an increase in the level of metabolites of the serotonergic system. The combined action of the two surfactants largely corresponded to the effect of the last introduced substance in the midbrain and cerebellum. The combined administration of these PAS had a significant impact on parameters of the dopaminergic and serotonergic systems manifested by the processes of dopamine catabolism and a decrease in the norepinephrine and serotonin concentrations in the hypothalamus and these changes were not observed after ethanol or morphine administration alone.

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乙醇和吗啡急性联合中毒大鼠脑内神经递质损伤

摘要:研究了急性吗啡和乙醇联合中毒大鼠下丘脑、中脑和小脑中生物源性单胺及其代谢产物的水平。用乙醇和吗啡对大鼠进行单一治疗会导致大脑特定部位的神经递质受损;他们依赖于吗啡和乙醇给药的顺序。与精神活性物质(PAS)的给药顺序无关，乙醇和吗啡联合中毒仅在下丘脑产生多巴胺利用的迹象。在酒精-吗啡中毒期间，在大脑的研究部分，血清素能系统的代谢物水平增加。这两种表面活性剂的联合作用在很大程度上与最后引入的物质在中脑和小脑中的作用相对应。这些PAS联合给药对多巴胺能和5 -羟色胺能系统的参数有显著影响，表现为多巴胺分解代谢过程和下丘脑去甲肾上腺素和5 -羟色胺浓度的降低，这些变化在单独给药乙醇或吗啡后未观察到。

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来源期刊

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

1.10

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0.00%

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期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.