The Study of the Cerebrospinal Fluid Cytokine Profile in Children with Acute Lymphocytic Leukemia and Neurotoxic Side Effects of Chemotherapy

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2022-02-14 DOI:10.1134/S1990750822010036

V. V. Bazarnyi, O. P. Kovtun, O. V. Koryakina, L. G. Polushina, A. Yu. Maksimova

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Abstract

In some cases standard chemotherapy of acute lymphocytic leukemia (ALL) leads to neurotoxicity; its mechanisms, methods of prognosis, and prevention are being actively studied. The aim of this study was to assess the cerebrospinal fluid (CSF) cytokine profile in children with ALL and neurotoxic side effects of chemotherapy. This prospective study included 24 children with ALL aged from 3 to 17 years. Patients were further subdivided into ALL patients with (the main group) and without neurological complications (the comparison group). The level of CSF cytokines was measured by the Xmap technology (Luminex) using Invitrogen test systems (eBioscience) and the Luminex 200 system. The comparative analysis of the cytokine profile in the group of children with chemotherapy-induced neurotoxic complications revealed elevated levels of chemokine CXCL12 (SDF-1α) and stem cell factor (SCF). The increased level of these cytokines in CSF suggested a relatively risk for development of the toxic peripheral neuropathy.

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急性淋巴细胞白血病患儿脑脊液细胞因子谱及化疗神经毒副作用的研究

在某些情况下，急性淋巴细胞白血病(ALL)的标准化疗导致神经毒性;目前正在积极研究其发病机制、预后和预防方法。本研究的目的是评估ALL患儿脑脊液(CSF)细胞因子谱和化疗的神经毒性副作用。这项前瞻性研究包括24名年龄在3至17岁之间的ALL儿童。患者进一步细分为有(主要组)和无神经系统并发症(对照组)的ALL患者。采用Xmap技术(Luminex)、Invitrogen检测系统(eBioscience)和Luminex 200系统检测CSF细胞因子水平。对化疗引起的神经毒性并发症患儿组细胞因子谱的比较分析显示趋化因子CXCL12 (SDF-1α)和干细胞因子(SCF)水平升高。脑脊液中这些细胞因子水平的升高表明中毒性周围神经病变的发展相对危险。

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Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

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1.10

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0.00%

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期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.