H. Safakhah, A. Rashidy-Pour, F. Mohammadzadeh, Abbas Ali Vafaei
{"title":"The effect of turmeric and curcumin on neuropathic pain behavioral response of CCI model in rats","authors":"H. Safakhah, A. Rashidy-Pour, F. Mohammadzadeh, Abbas Ali Vafaei","doi":"10.29252/jmp.19.75.141","DOIUrl":null,"url":null,"abstract":"Abbreviations: CCI, Chronic Constriction Injury; DNA, Deoxyribonucleic Acid; TNF-α, Tumor necrosis factor alpha; NO, Nitric Oxide; NADH, Nicotinamide Adenine Dinucleotide Hydrogen; LDH, Lactate dehydrogenase; Background: Neuritis is one of the causes of neuropathic pains. It is proved that turmeric and curcumin have anti-neuritis effect that may be reduce of neuropathic pain. Objective: In this study, effects of turmeric and curcumin have been evaluated on behavioral response resulted from chronic constriction injury (CCI) in rat. Methods: In this experimental study Wistar male rat (200-250 gr) were used. For create of CCI, Bennet and Xie (1988) method has been used. 2 weeks after neuritis occurrence, turmeric 60 mg/kg and curcumin 30 and 60 mg/kg injection have been begun and continued until 26 th day as","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medicinal Plants","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29252/jmp.19.75.141","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Abbreviations: CCI, Chronic Constriction Injury; DNA, Deoxyribonucleic Acid; TNF-α, Tumor necrosis factor alpha; NO, Nitric Oxide; NADH, Nicotinamide Adenine Dinucleotide Hydrogen; LDH, Lactate dehydrogenase; Background: Neuritis is one of the causes of neuropathic pains. It is proved that turmeric and curcumin have anti-neuritis effect that may be reduce of neuropathic pain. Objective: In this study, effects of turmeric and curcumin have been evaluated on behavioral response resulted from chronic constriction injury (CCI) in rat. Methods: In this experimental study Wistar male rat (200-250 gr) were used. For create of CCI, Bennet and Xie (1988) method has been used. 2 weeks after neuritis occurrence, turmeric 60 mg/kg and curcumin 30 and 60 mg/kg injection have been begun and continued until 26 th day as
期刊介绍：
The Journal of Medicinal Plants is published quarterly. This journal contains articles in the fields of basic and clinical sciences related to medicinal plants including pharmacognosy, basic and clinical pharmacology, basic and clinical toxicology, and pharmacology.
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