Clinicopathological features of colorectal cancers in Morocco based on the registry of the National Institute of Oncology in Rabat

Abstract

Background and objectives: Colorectal cancer (CRC) is rising steadily, particularly in developing nations. In Morocco, colorectal cancer is ranking third most incident. Via this study, we present the epidemiological profile, clinical features of colorectal cancers, and chemotherapy outcome in a Moroccan population. Materials and methods: This study is a retrospective investigation, run between January and December 2013 of 290 patients with colorectal cancer. A descriptive and analytical study was carried out via statistical analysis to correlate clini- copathological data with overall chemotherapy-related toxicity occurrence, by the Chi2 test. The non-parametric Mann-Whitney test was used for comparison between the occurrence of diarrhea and bilirubin levels. Results: Most of the cases were between 40–59 years, and 50.5% (n = 147) were men. KRAS (12, 13 codon) was mutant in 10 patients (3.4%). Chemotherapy was administered to 146 patients (50.4%), and 85.6% had suffered from at least one toxic event during CMT treatment. The mean total bilirubin and mean conjugated bilirubin were found to be significantly high in patients who do not de- velop diarrhea, compared to those with diarrheal toxicity with a p-value of 0.02 and 0.03 respectively. Conclusion: Our study reveals a significant percentage of toxicity occurrence among patients who underwent chemothera- py.