Rotavirus Infection in Neonates and Young Infants

Abstract

Rotavirus is the primary cause of acute, frequently severe gastroenteritis among growing premature neonates, young infants, and children under the age of five globally. It contains a double-stranded ribonucleic acid genome is a member of the Reoviridae family. In this review, we have discussed the structure and characteristics of the virus, the pathogenesis of rotaviral diarrhea, clinical features, methods of diagnosis, clinical management, and available vaccines. This article combines peer-reviewed evidence from our own clinical studies with results of an extensive literature search in the databases PubMed, EMBASE, and Scopus.