{"title":"In vitro to in vivo translation","authors":"William B. Mattes","doi":"10.1016/j.cotox.2020.09.001","DOIUrl":null,"url":null,"abstract":"<div><p>The science of <em>in vitro</em> studies has advanced dramatically over the last 100 years, particularly in regards to their application in toxicology. Recent developments such as <em>in vitro</em> three-dimensional cultures and microphysiological systems have offered the promise of even greater replication of <em>in vivo</em> function. Nonetheless, the challenge of validating a system's performance and extrapolating it's responses to those of an animal or human remains</p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.09.001","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202020300528","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
The science of in vitro studies has advanced dramatically over the last 100 years, particularly in regards to their application in toxicology. Recent developments such as in vitro three-dimensional cultures and microphysiological systems have offered the promise of even greater replication of in vivo function. Nonetheless, the challenge of validating a system's performance and extrapolating it's responses to those of an animal or human remains
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