{"title":"In vitro to in vivo translation","authors":"William B. Mattes","doi":"10.1016/j.cotox.2020.09.001","DOIUrl":null,"url":null,"abstract":"<div><p>The science of <em>in vitro</em> studies has advanced dramatically over the last 100 years, particularly in regards to their application in toxicology. Recent developments such as <em>in vitro</em> three-dimensional cultures and microphysiological systems have offered the promise of even greater replication of <em>in vivo</em> function. Nonetheless, the challenge of validating a system's performance and extrapolating it's responses to those of an animal or human remains</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"23 ","pages":"Pages 114-118"},"PeriodicalIF":3.6000,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.09.001","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202020300528","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 11
Abstract
The science of in vitro studies has advanced dramatically over the last 100 years, particularly in regards to their application in toxicology. Recent developments such as in vitro three-dimensional cultures and microphysiological systems have offered the promise of even greater replication of in vivo function. Nonetheless, the challenge of validating a system's performance and extrapolating it's responses to those of an animal or human remains
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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