Perspective of tumor heterogeneity for treatments of intrahepatic cholangiocarcinoma with intrahepatic lithiasis

Wenjie Hou, Yifan Tu, M. Zheng, Q. Zeng
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Abstract

The heterogeneity of tumors results in significantly distinct biological characteristics of intrahepatic cholangiocarcinoma (ICC) caused by different etiologies. Among them, ICC caused by intrahepatic lithiasis (IHL-ICC) presents challenges in early detection, tumor staging, and surgical treatment, and has the poorest prognosis among all etiologies of ICC patients. Thus, it is essential to focus on early assessment of the possibility of developing ICC, prompt intervention of intrahepatic lithiasis, anatomical resection of hepatic parenchyma corresponding to the branch of the intrahepatic bile duct undergoing cancerous transformation, and enhanced postoperative follow-up of hepatolithiasis and ICC for IHL-ICC patients. These interventions are crucial to improve the clinical outcomes and overall survival of IHL-ICC patients.
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肿瘤异质性对肝内胆管癌合并肝内结石治疗的影响
肿瘤的异质性导致不同病因导致的肝内胆管癌(ICC)的生物学特征有显著差异。其中,肝内结石(IHL-ICC)引起的ICC在早期发现、肿瘤分期和手术治疗方面存在挑战,在所有病因中预后最差。因此,早期评估发生ICC的可能性,及时干预肝内结石,解剖切除发生癌性转化的肝内胆管分支对应的肝实质,加强对IHL-ICC患者肝内结石和ICC的术后随访至关重要。这些干预措施对于改善IHL-ICC患者的临床结果和总体生存至关重要。
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