SPR-Based Label-Free Sensor for RI-Based Detection of Urea Concentration

IF 3.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL Plasmonics Pub Date : 2023-07-22 DOI:10.1007/s11468-023-01956-0

Lokendra Singh, Abdulkarem H. M. Almawgani, Yesudasu Vasimalla, Roshan Kumar, Turki Alsuwian

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Abstract

The real-time, label-free, and high sensitivity are the inherent advantages of surface plasmon resonance (SPR) technology, making it the most versatile tool for sensing the street. It has been extensively used in various fields such as healthcare, management of the environment, and food-borne diseases. In the last several decades, kidney-related issues become more serious and resulting in physical degeneration and even death. The glomerular filtration rate (GFR) defines the functioning of the kidney concerning blood filtration. The GFR rate gets degraded with the increase in urea concentration in human bodies. Therefore, this study presents a highly sensitive gold nanoparticle SPR sensor based on an angular interrogation method for the enzymatic detection of urea samples. The biocompatibility of the sensor is enhanced by functionalizing the sensor with layers of molybdenum disulfide (MoS₂) and cerium oxide (CeO₂). Exposing the sensor to analytes without any biocompatible layer achieves a maximum sensitivity of 186.50°/RIU. On the other hand, a maximum sensitivity of 217.50°/RIU and 275°/RIU is attained for Au/MoS₂/urease and Au/CeO₂/urease combinations, respectively.

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基于SPR的无标记传感器用于基于RI的尿素浓度检测

表面等离子体共振(SPR)技术的实时性、无标签性和高灵敏度是其固有的优势，使其成为最通用的街道传感工具。它已广泛应用于医疗保健、环境管理和食源性疾病等各个领域。在过去的几十年里，肾脏相关的问题变得越来越严重，导致身体退化甚至死亡。肾小球滤过率(GFR)定义了肾脏在血液过滤方面的功能。GFR速率随着人体内尿素浓度的增加而降低。因此，本研究提出了一种基于角度询问法的高灵敏度金纳米粒子SPR传感器，用于尿素样品的酶解检测。通过二硫化钼(MoS2)和氧化铈(CeO2)层功能化传感器，增强了传感器的生物相容性。将传感器暴露于没有任何生物相容性层的分析物中，可获得186.50°/RIU的最大灵敏度。而Au/MoS2/脲酶和Au/CeO2/脲酶的最大灵敏度分别为217.50°/RIU和275°/RIU。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.