Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation.

IF 3.1 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemical Research in Chinese Universities Pub Date : 2022-01-01 Epub Date: 2022-05-07 DOI:10.1007/s40242-022-2087-9

Sisi Chen, Lei Zhang, Quan Yuan, Jie Tan

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引用次数: 1

Abstract

The interaction between biomolecules with their target ligands plays a great role in regulating biological functions. Aptamers are short oligonucleotide sequences that can specifically recognize target biomolecules via structural complementarity and thus regulate related biological functions. In the past ten years, aptamers have made great progress in target biomolecule recognition, becoming a powerful tool to regulate biological functions. At present, there are many reviews on aptamers applied in biomolecular recognition, but few reviews pay attention to aptamer-based regulation of biological functions. Here, we summarize the approaches to enhancing aptamer affinity and the advancements of aptamers in regulating enzymatic activity, cellular immunity and cellular behaviors. Furthermore, this review discusses the challenges and future perspectives of aptamers in target recognition and biological functions regulation, aiming to provide some promising ideas for future regulation of biomolecular functions in a complex biological environment.

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基于适配体的生物分子识别与生物过程调控研究进展

生物分子与其靶配体之间的相互作用在调节生物功能方面发挥着重要作用。适体是一种短寡核苷酸序列，可以通过结构互补性特异性识别靶生物分子，从而调节相关的生物功能。在过去的十年里，适体在靶生物分子识别方面取得了巨大进展，成为调节生物功能的有力工具。目前，关于适体在生物分子识别中的应用有很多综述，但很少有综述关注基于适体的生物功能调控。在此，我们总结了增强适体亲和力的方法以及适体在调节酶活性、细胞免疫和细胞行为方面的进展。此外，本文还讨论了适体在靶标识别和生物功能调控方面的挑战和未来前景，旨在为未来在复杂生物环境中调控生物分子功能提供一些有前景的思路。

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来源期刊

Chemical Research in Chinese Universities 化学-化学综合

CiteScore

5.30

自引率

6.50%

发文量

152

审稿时长

3.0 months

期刊介绍： The journal publishes research articles, letters/communications and reviews written by faculty members, researchers and postgraduates in universities, colleges and research institutes all over China and overseas. It reports the latest and most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across subdisciplines. Main research areas include (but are not limited to): Organic chemistry (synthesis, characterization, and application); Inorganic chemistry (bio-inorganic chemistry, inorganic material chemistry); Analytical chemistry (especially chemometrics and the application of instrumental analysis and spectroscopy); Physical chemistry (mechanisms, catalysis, thermodynamics and dynamics); Polymer chemistry and polymer physics (mechanisms, material, catalysis, thermodynamics and dynamics); Quantum chemistry (quantum mechanical theory, quantum partition function, quantum statistical mechanics); Biochemistry; Biochemical engineering; Medicinal chemistry; Nanoscience (nanochemistry, nanomaterials).