Modelling tumour–immune dynamics, disease progression and treatment

Abstract

While incredible efforts have been made over the past decades to decipher the complexity of tumour–immune interactions, there is still a growing need for innovative quantitative modelling approaches that account for the complexity of tumour–immune dynamics. Mathematical modelling can shed light on the multifaceted processes implicated in this new type of therapy, such as the dynamics of immune activation and regulation, immune responses against tumour, tumour suppression of immune cells, the impact of the tumour environment, tumour escape mechanisms and recent advances in cancer therapies.