N-pendent dimethyl derivative of an octamethyl azamacrocycle and its Cu(II), Ni(II) and Zn(II) complexes: synthesis, characterization and antimicrobial investigations
Suman Kanti Das Gupta, Saswata Rabi, Benu Kumar Dey, Axel Buchholz, Winfried Plass, Tapashi Ghosh Roy
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引用次数: 0
Abstract
Purpose
Due to the mentionable importance of macrocyclic compounds different metal complexes with a new macrocyclic ligand have been prepared in this study. To materialize this expectation, a new N-pendent derivative LAZ was prepared by the interaction between isomeric ligand, LA (a C-chiral isomer of 3,10-C-meso-Me8[14]ane) and CH3I at 1:4 ratio under reflux in methanolic solution. LAZ underwent complexation with Ni(II), Cu(II) and Zn(II) salts to form four coordinated square planar orange [NiLAZ](ClO4)2 square planar violet [CuLAZ](ClO4)2, and five coordinated square pyramidal white [ZnLAZ(NO3)](NO3) complexes respectively. The axial addition reactions on [CuLAZ](ClO4)2 with NCS−, NO3−, NO2−, Cl−, Br− and I− afforded different colored six coordinated octahedral axial addition products: purple [CuLAZ(NCS)2]; pink [CuLAZ(NO3)(ClO4)]; pink [CuLAZ(NO2)(ClO4)]; pink [CuLAZCl(ClO4)]; pink [CuLAZBr2] and deep blue [CuLAZI(ClO4)] respectively.
Methods
The compounds were characterized on the basis of different analytical parameters. Antibacterial and antifungal activities of newly prepared compounds were investigated by using standard methods.
Results
The metal complexes of LAZ showed different geometries with required coordination. Theses complexes also showed electrolytic behavior in different solvents. The ligand LAZ and its metal complexes exhibit moderate antimicrobial activities toward different phytopathogenic bacteria and fungi.
期刊介绍：
The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites.
The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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