The Association between Nutritional Status and Parasite Density in Children with Vivax Malaria in Kualuh Leidong, Indonesia

Abstract

Background: Nutritional status is believed to affect the immune system and parasite density in children diagnosed with malaria from Plasmodium vivax infection. It is known that nutritional status could facilitate the growth of protective immune response towards malaria antigen, but some studies have shown that poor nutrition could cause clinical complications and lead to severe malaria. There have also been different reports on the relationship between nutritional status and parasite density. Objectives: This study aimed to examine the association between nutritional status and parasite density in children with vivax malaria in Kualuh Leidong area. Methods: This cross-sectional study was conducted from October 2019 to January 2020 in Kualuh Leidong to investigate 48 children aged between 2 - 18 and diagnosed with vivax malaria. The nutritional status of children with fever and positive Plasmodium vivax confirmed by microscopic examination were evaluated. Parasite density was determined in order to assess the severity of the infection. A non-parametric test was performed to examine the association between these two conditions. Results: There was a significant association (P = 0.032) between sexual parasite density and nutritional status. A post hoc test showed that overweight or mild malnutrition significantly correlated (P = 0.029) with high sexual parasite density. However, no significant association was found between nutritional status and asexual parasite density (P = 0.222).