MOG antibody-related disorder associated with peripheral facial nerve palsy

Abstract

A 44-year-old Japanese woman exhibited neurological symptoms including unsteadiness of gait, headache, hypoesthesia of the left face, and left-sided peripheral facial nerve palsy. Brain magnetic resonance imaging (MRI) revealed abnormal intensities in the hemispheres, brainstem, and corpus callosum. Although routine blood and cerebrospinal fluid studies were unremarkable, serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive. With two-time intravenous methylprednisolone pulse therapy, her symptoms gradually improved. We report here a rare case of a MOG antibody-related disorder with peripheral facial nerve palsy as a predominant symptom. We should be aware of this disease even in a case of peripheral facial nerve palsy.