The Inflammatory Effect of Epigenetic Factors and Modifications in Depressive Disorder: A Review.

Keming Qi, Yi Yu, Jiang Guan, Jiayuan Zhang, Wei Lu, Yicong Wei
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Abstract

Background Depressive disorder is one of the most common mental diseases and has become one of the three major causes of disability worldwide. Although some of the pathological mechanisms have been analyzed, the corresponding drug therapy has only achieved about 30% of curative effects. However, the pathological mechanism of depression is very complex, and the relationship between its complicated pathological mechanisms is still elusive. In recent years, there is more and more evidence that environmental stress induces stable changes in gene expression through the epigenetic mechanism and plays a vital role in the pathogenesis of the disease. Among them, neuroinflammation was considered to be a key pathological mechanism. Objective To explore the relationship between epigenetic mechanism and neuroinflammation in the pathological process of depression. Methods In this paper, we review the crucial role of neuroinflammation in complex pathological mechanisms, especially its complex interrelationship with neurotransmitters, neuroendocrine, neurogenesis, and neuronal plasticity, which play a key role in the pathology of depression. Results The relationship between epigenetic mechanism and neuroinflammation in the pathological process of depression was discussed, which mainly involves histone acetylation, histone methylation, DNA methylation, and non-coding RNA association. Conclusion This review will help to understand the role of epigenetic mechanisms in depression and its related inflammatory responses and provides direction and guidance for future research.
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表观遗传因素在抑郁症中的炎症作用及其修饰:综述。
背景抑郁症是最常见的精神疾病之一,已成为世界范围内致残的三大原因之一。尽管已经分析了一些病理机制,但相应的药物治疗仅取得了约30%的疗效。然而,抑郁症的病理机制非常复杂,其复杂病理机制之间的关系仍然难以捉摸。近年来,越来越多的证据表明,环境应激通过表观遗传学机制诱导基因表达的稳定变化,并在疾病的发病机制中发挥着至关重要的作用。其中,神经炎症被认为是一种重要的病理机制。目的探讨抑郁症病理过程中表观遗传学机制与神经炎症的关系。方法本文综述了神经炎症在复杂病理机制中的重要作用,特别是其与神经递质、神经内分泌、神经发生和神经元可塑性的复杂相互关系,这些在抑郁症的病理中起着关键作用。结果探讨了抑郁症病理过程中表观遗传学机制与神经炎症的关系,主要涉及组蛋白乙酰化、组蛋白甲基化、DNA甲基化和非编码RNA结合。结论这篇综述将有助于理解表观遗传学机制在抑郁症及其相关炎症反应中的作用,并为未来的研究提供方向和指导。
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来源期刊
Central nervous system agents in medicinal chemistry
Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology
CiteScore
2.10
自引率
0.00%
发文量
21
期刊介绍: Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
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