WTAP: a new player in postnatal BAT development

Sun Lei
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Abstract

Understanding the mechanisms underlying brown fat development and metabolism can provide unique insights into the regulation of energy homeostasis. In a recent study published in Life Metabolism, Wang et al. established Wilms’ tumor 1-associating protein (WTAP), a key component in m 6A methyltransferase complex, as a new and essential regulator in the postnatal development and maturation of interscapular brown adipose tissue (iBAT).
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WTAP:产后BAT发展的新玩家
了解棕色脂肪发育和代谢的机制可以为能量稳态的调节提供独特的见解。在最近发表在《生命代谢》杂志上的一项研究中,王等人将m 6A甲基转移酶复合物中的关键成分威尔姆斯肿瘤1相关蛋白(WTAP)确定为出生后囊间棕色脂肪组织(iBAT)发育和成熟的新的重要调节因子。
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