IN-SILICO PERFORMANCE INVESTIGATION OF NANOPARTICLE-ASSISTED PHOTO THERMAL ABLATION

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-12-31 DOI:10.1142/s0218339023500055

Torikul Islam Palash, M. R. Kaysir, Md Jahirul Islam, Sabiha Aziz, Taskia Nadriba Mimma, N. Akther

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引用次数: 1

Abstract

In recent days, the number of cancer cases is escalating promptly around the world. In general, conventional ablation methods, encompassing comprehensive drawbacks, are employed to cure cancer. At present, photo thermal therapy (PTT) is showing great promise to the treatment of cancer. However, the effective implementation of this technology is utmost challenging as several parameters affect the tumor surroundings. In this work, the effects of different parameters on the performance of PTT have been thoroughly investigated by considering a realistic model of human tissue underneath the skin using a finite element solver, COMSOL Multiphysics. Two different conditions, with and without considering gold nanoparticles at tumor site, are investigated where a laser beam is used as a source of energy. Fluence rate, temperature distribution, and thermal damage are highlighted in this work. It is observed that by utilizing a miniature needle with integrated waveguide and gold nanoparticles, a tumor can be effectively eradicated along with assuaging the conventional drawbacks of PTT. This study would also be useful for designing operative PTT for different parts of human tissue.

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纳米颗粒辅助光热烧蚀的硅内性能研究

最近几天，世界各地的癌症病例数量正在迅速上升。一般来说，传统的消融术被用来治疗癌症，但缺点很多。目前，光热疗法(PTT)在治疗癌症方面显示出巨大的前景。然而，该技术的有效实施极具挑战性，因为有几个参数会影响肿瘤环境。在这项工作中，通过使用有限元求解器COMSOL Multiphysics考虑皮肤下人体组织的现实模型，深入研究了不同参数对PTT性能的影响。研究了两种不同的条件，在肿瘤部位考虑金纳米粒子和不考虑金纳米粒子，其中激光束被用作能量来源。在这项工作中强调了通量、温度分布和热损伤。研究发现，利用集成波导和金纳米粒子的微型针头，可以有效地根除肿瘤，同时减轻了PTT传统的缺点。本研究对设计人体组织不同部位的手术PTT也有一定的指导意义。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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