A. Aykaç, Hüseyin Şah, A. Kükner, S. Sayıner, A. Sehirli
{"title":"Effects of Chitosan on Cisplatin-Induced Hepatorenal Toxicity in an Animal Model","authors":"A. Aykaç, Hüseyin Şah, A. Kükner, S. Sayıner, A. Sehirli","doi":"10.4274/imj.galenos.2022.54077","DOIUrl":null,"url":null,"abstract":"hepatorenal damage was reversed with CTS treatment in the renal and hepatic tissues (p<0.05). Overall, CIS-induced increases in apoptotic parameters, Bcl-2/Bax ratio and caspase-3 expression, were reversed by CTS treatment (p<0.05). Conclusion: It was determined that CTS, a biopolymer, may have a protective effect by preventing hepatorenal damage caused by CIS. ABSTRACT","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Istanbul Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/imj.galenos.2022.54077","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
hepatorenal damage was reversed with CTS treatment in the renal and hepatic tissues (p<0.05). Overall, CIS-induced increases in apoptotic parameters, Bcl-2/Bax ratio and caspase-3 expression, were reversed by CTS treatment (p<0.05). Conclusion: It was determined that CTS, a biopolymer, may have a protective effect by preventing hepatorenal damage caused by CIS. ABSTRACT
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