Trisha Mitra, S. Joardar, S. Chakravorty, Manoj Majumdar, M. Kundu, B. Roy
{"title":"Palladium-Mediated Reductive Heck Cyclization for the Synthesis of Fused Retinoid Derivatives","authors":"Trisha Mitra, S. Joardar, S. Chakravorty, Manoj Majumdar, M. Kundu, B. Roy","doi":"10.1055/a-2022-3227","DOIUrl":null,"url":null,"abstract":"Linearly fused Retinoids derivatives have been synthesized via a straightforward pathway using palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four step linear approach utilizing iodination, sulfonylation or benzylation or esterfication, palladium- catalyzed Sonogashira cross-coupling and palladium mediated reductive Heck cyclization.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"SynOpen","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2022-3227","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 1
Abstract
Linearly fused Retinoids derivatives have been synthesized via a straightforward pathway using palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four step linear approach utilizing iodination, sulfonylation or benzylation or esterfication, palladium- catalyzed Sonogashira cross-coupling and palladium mediated reductive Heck cyclization.