Palladium-Mediated Reductive Heck Cyclization for the Synthesis of Fused Retinoid Derivatives

IF 2 Q2 CHEMISTRY, ORGANIC SynOpen Pub Date : 2022-12-17 DOI:10.1055/a-2022-3227
Trisha Mitra, S. Joardar, S. Chakravorty, Manoj Majumdar, M. Kundu, B. Roy
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引用次数: 1

Abstract

Linearly fused Retinoids derivatives have been synthesized via a straightforward pathway using palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four step linear approach utilizing iodination, sulfonylation or benzylation or esterfication, palladium- catalyzed Sonogashira cross-coupling and palladium mediated reductive Heck cyclization.

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钯介导的还原Heck环化反应合成熔融类维甲酸衍生物
利用钯催化的还原Heck环化策略,通过简单的途径合成了线性融合的类维甲酸衍生物。通过碘化、磺化、苄基化或酯化、钯催化的Sonogashira交叉偶联和钯介导的还原Heck环化四步线性合成。
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来源期刊
SynOpen
SynOpen CHEMISTRY, ORGANIC-
CiteScore
2.30
自引率
4.00%
发文量
35
审稿时长
6 weeks
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