"THE RISK FACTORS OF SEVERE LEPTOSPIROSIS IN THE TRANSCARPATHIAN REGION OF UKRAINE – SEARCH FOR „RED FLAGS”"

Abstract

leptospirosis in the period from 2009 to 2019 was conduct-ed. Quantitative variables in the presence of normal distribution were compared using a paired Student’s t-test, and in the case of an abnormal distribution, the Mann–Whitney U test was used. The criterion χ 2 was used for qualitative variables. A two-step cluster analysis was also performed. précoces et d’un ajustement thérapeutique. Mots-clés: la leptospirose, mortalité, prédicteurs, facteurs de risque Results. The following factors associated with death from leptospirosis have been identified: oliguria (OR, 13.5; 95% confidence interval [CI], 2.56-71.12), serum creatinine and urea levels, direct and total bilirubin, platelets, and white blood cells count. Conclusions. These „red flag” laboratory and clinical characteristics will aid medical personnel in rapidly identifying a patient at risk of death, which is critical in determining the severity of the condition and the need for early intensive care and therapy adjustment. direct toxic injury, immune-mediated responses, and circulatory collapse 19 . The results of our study suggest that risk stratifica-tion for patients with leptospirosis should not be relied on the presence of icterus. Jaundice occurs because of damage to the vessels of the hepatic capillaries without hepatocellular necrosis. There are retrospective studies that confirm 20,21 , or deny 9,10 the role of jaundice as a predictor of death in this infectious disease.