Phytochemical composition, antioxidant, and anti-inflammatory activities of essential oil of Acmella uliginosa (Sw.) Cass. grown in North India Terai region of Uttarakhand

IF 1.6 Q3 URBAN STUDIES TOWN PLANNING REVIEW Pub Date : 2021-03-01 DOI:10.30495/TPR.2021.680495

K. Gairola, Shriya Gururani, Ravendra Kumar, O. Prakash, S. Agarwal, S. Dubey

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引用次数: 1

Abstract

The plant Acmella uliginosa (Sw.) Cass. belonging to family Asteraceae was subjected to hydro distillation for essential oil extraction and was chemically analyzed by GC/MS for its phytochemical composition. Thirty-five compounds were identified comprising 88.1% of total essential oil composition. Limonene (12.2%) along with sesquisabinene isomer (7.3%) and caryophyllene oxide (5.9%) were the prominent compounds of the essential oil. In-vitro antioxidant activity of essential oil was investigated by DPPH free radical scavenging activity and metal chelating activity having IC50 value of 326.77 ± 5.34 μL and 14.853 ± 0.106 μL respectively whereas reducing power activity having RP50 value of 14.011 ± 0.0446 μL. The essential oil exhibited potent anti-inflammatory activity with IB50 value of 5.629 ± 0.0311 μL compared to standard Diclofenac sodium salt having IB50 value of 23.693 ± 0.306 μg/mL. The essential oil displayed exceedingly marked anti-inflammatory as well as antioxidant activities as compared to standard marketed drugs.

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木犀草挥发油的植物化学成分及抗氧化抗炎活性卡斯。生长在印度北部的北阿坎德邦的Terai地区

植物Acmella uliginosa（Sw.）Cass。对菊科植物进行了加氢蒸馏提取精油，并用GC/MS对其植物化学成分进行了化学分析。鉴定出35种化合物，占精油总成分的88.1%。柠檬烯（12.2%）、倍半沙宾烯异构体（7.3%）和氧化石竹烯（5.9%）是该精油的主要化合物。通过DPPH自由基清除活性和金属螯合活性研究了精油的体外抗氧化活性，IC50值分别为326.77±5.34μL和14.853±0.106μL，而还原力活性为14.011±0.0446μL。与IB50值为23.693±0.306μg/mL的标准双氯芬酸钠盐相比，精油表现出强大的抗炎活性，IB50值是5.629±0.0311μL。与标准上市药物相比，这种精油表现出极其显著的抗炎和抗氧化活性。

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来源期刊

TOWN PLANNING REVIEW URBAN STUDIES-

CiteScore

3.40

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0.00%

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期刊介绍： Town Planning Review has been one of the world"s leading journals of urban and regional planning since its foundation in 1910. With an extensive international readership, TPR is a well established urban and regional planning journal, providing a principal forum for communication between researchers and students, policy analysts and practitioners. To mark TPR’s centenary in 2010, it is proposed to publish a series of ‘Centenary Papers’ -- review papers that record and reflect on the state of the art in a range of topics in the general field of town and regional planning.