Development of the Formulation and Evaluation of the Anti-infl ammatory Activity of Vitex negundo Gel and Latex

Abstract

Essential oils include Vitex negundo Linn. It is used in the treatment of eye diseases, toothache, redness, white spots, splenomegaly, skin ulcers, catarrh, rheumatoid arthritis, gonorrhea and bronchitis. It is also used as a tonic, insect repellent, emulsifi er, menstrual aid, antibacterial, antipyretic and antihistamine. Preparations from plant parts of V. negundo treat a variety of ailments, including rheumatic diseases, arthritis, gout, cervicitis, infl ammatory diseases of the musculoskeletal system, hemorrhoids (thousands), rheumatic pains, sprains and toothaches. It has been used commercially for miles in various Ayurvedic remedies and ointments to treat wounds, burns, and fungal skin infections. We concluded from in vitro drug delivery studies that latex composed of HPMC polymers facilitates controlled release of drugs over long periods of time, avoids further fl uctuations, and reduces treatment costs. This new class of drug delivery is gaining popularity due to the spreadability, adhesion, viscosity and extrudability properties of emulgel, which makes topical application of hydrophobic pills desirable for every near and systemic eff ect.