Promising effects of naringenin and melatonin against hepatic encephalopathy impairments induced by bile duct ligation in male rats.

Q3 Psychology Central nervous system agents in medicinal chemistry Pub Date : 2022-03-14 DOI:10.2174/1871524922666220314123052

Elahe Karami Raviz, Fatemeh Noormand, Ali Sharifzadeh Kermani, Ali Galedari, K. Esmaeilpour, M. Maneshian, T. Kalantaripour, S. Dabiri, M. A. Shekaari

{"title":"Promising effects of naringenin and melatonin against hepatic encephalopathy impairments induced by bile duct ligation in male rats.","authors":"Elahe Karami Raviz, Fatemeh Noormand, Ali Sharifzadeh Kermani, Ali Galedari, K. Esmaeilpour, M. Maneshian, T. Kalantaripour, S. Dabiri, M. A. Shekaari","doi":"10.2174/1871524922666220314123052","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nBile duct ligation (BDL) has been used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) were used as protectants in various models of diseases.\n\n\nAIM\nIn the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats.\n\n\nMETHODS\nThe animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments. <p.\n\n\nRESULTS\nBased on the data, BDL resulted in the decreasing locomotor activity, which was reversed by N and M. Morphological study confirmed that BDL led to neurodegeneration in the cortex of the rats, and the N and M treatment preserved cortical neurons. In addition, immunohistochemical (IHC) study of the rat cortex showed that BDL resulted in increasing the activated astrocytes, and the N and M treatment reduced the number of activated cells.\n\n\nCONCLUSION\nThese results obviously depicted that combinational therapy with N and M had positive effects in the BDL rats, probably due to their synergistic anti-inflammatory and antioxidant activities.","PeriodicalId":9799,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central nervous system agents in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871524922666220314123052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Psychology","Score":null,"Total":0}

引用次数: 1

Abstract

BACKGROUND Bile duct ligation (BDL) has been used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) were used as protectants in various models of diseases. AIM In the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats. METHODS The animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

柚皮素和褪黑激素对雄性大鼠胆管结扎引起的肝性脑病损伤的潜在作用。

背景胆管结扎(BDL)已被用于评估不同抗炎和抗氧化药物对肝和脑损伤的保护作用。柚皮素(N)和褪黑素(M)被用作各种疾病模型的保护剂。本研究探讨了上述抗炎、抗氧化剂对雄性大鼠BDL脑损伤的联合作用。方法将大鼠分为Sham组、BDL+ Vehicle组和BDL+ N + m组，采用生化、运动行为任务和形态学评价神经损伤。< p。结果BDL导致大鼠运动活动减少，而N和M可逆转这一趋势。形态学研究证实BDL导致大鼠皮层神经退行性改变，N和M处理保留了皮层神经元。此外，大鼠皮层免疫组化(IHC)研究表明，BDL导致激活的星形胶质细胞增加，N和M处理减少了激活的细胞数量。结论N、M联合治疗BDL大鼠可能具有协同抗炎和抗氧化作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.