What is a Bladder Cancer Molecular Subtype?

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-12-13 eCollection Date: 2023-01-01 DOI:10.3233/BLC-220124

Mattias Höglund

引用次数: 0

Abstract

Background: Several molecular classification systems for bladder cancer have been proposed, but due to differences on how to define molecular subtypes, controversies and misunderstandings have arisen.

Objective: To discuss different aspects of the molecular classification of bladder cancer and to point to the consequences of using different conceptual approaches. To question some underlying assumptions when defining molecular subtypes.

Methods: To critically reflect on some of the principles and methods used when defining molecular subtypes.

Results: Depending on underlying assumptions and aims for the definitions of subtypes, different types of molecular subtypes will be arrived at.

Conclusion: The underlying assumptions and their consequences must be better clarified when defining molecular subtypes.

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什么是膀胱癌症分子亚型？

背景：目前已提出了多种癌症的分子分类系统，但由于分子亚型的定义存在差异，引起了争议和误解。目的：讨论癌症分子分类的不同方面，并指出使用不同概念方法的后果。在定义分子亚型时质疑一些基本假设。方法：批判性地反思定义分子亚型时使用的一些原则和方法。结果：根据亚型定义的基本假设和目的，将得出不同类型的分子亚型。结论：在定义分子亚型时，必须更好地阐明基本假设及其后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.