Adipokines from adipose tissue and common variable immunodeficiency: Is there any association?

IF 5.5 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2023-09-01 Epub Date: 2023-06-05 DOI:10.1111/sji.13257

Luana Amorim Hassun, Maria Luiza Ricarte Ruggeri, Stefany Alvino de Souza, Alice Mory Rossato, Gabriela Souza Chmieleski, Larissa Scarpini de Carvalho, Adriana Gut Lopes Riccetto, Giovanna Rosa Degasperi

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Abstract

Adiponectin and leptin are adipokines, secreted by white adipose tissue (WAT), which play an important role in energy homeostasis. Some evidence has shown that adipokine-producing adipose cells present in the bone marrow (BM) appear to exert an influence on hematopoiesis and B cell development. Common variable immunodeficiency (CVID) is one of the most common inborn errors of immunity in humans. In CVID, numerical and/or functional defects of B cells and their precursors result in hypogammaglobulinemia, usually Immunoglobulin (Ig) A and IgG. Manifestations of CVID include immunodeficiency, autoimmunity, inflammation and lymphoproliferation, resulting in a wide range of phenotypes. How adipokines interact and influence the pathophysiology of CVID is still unclear. In this review, we seek to summarize the aspects known so far concerning the interface between adipokines, B cells and CVID. More research is needed to fully understand these interactions; this knowledge is a potential avenue for the discovery of useful biomarkers and may provide new therapeutic targets for the treatment of patients with CVID and related diseases.

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来自脂肪组织的脂肪因子和常见的可变免疫缺陷:有什么联系吗?

脂联素和瘦素是由白色脂肪组织(WAT)分泌的脂肪因子，在能量稳态中起重要作用。一些证据表明，骨髓中产生脂肪因子的脂肪细胞(BM)似乎对造血和B细胞的发育有影响。共同可变免疫缺陷(CVID)是人类最常见的先天性免疫缺陷之一。在CVID中，B细胞及其前体的数量和/或功能缺陷导致低γ球蛋白血症，通常是免疫球蛋白(Ig) A和IgG。CVID的表现包括免疫缺陷、自身免疫、炎症和淋巴细胞增殖，导致广泛的表型。脂肪因子如何相互作用并影响CVID的病理生理尚不清楚。在这篇综述中，我们试图总结迄今为止已知的关于脂肪因子，B细胞和CVID之间界面的方面。需要更多的研究来充分理解这些相互作用;这一知识是发现有用生物标志物的潜在途径，并可能为CVID患者和相关疾病的治疗提供新的治疗靶点。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.

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