Correlation of Biomechanical Features of Keratoconus Patients with Severity of Disease

Q4 Medicine pzshkhy blyny bn syn Pub Date : 2019-03-15 DOI:10.21859/AJCM.25.4.200
R. Sorkhabi, P. Khatibian, دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز
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Abstract

Background and Objective: Keratoconus is a disorder in cornea characterized by constant thinning and prominence that can result in vision defect. Due to ultrasonic changes in the corneal structure caused by keratoconus disease, its rigidity and biomechanical properties are subject to some changes. In this regard, the present study was conducted to determine the correlation of biomechanical features of keratoconus patients with the severity of the disease. Materials and Methods: The case group was selected from the patients with keratoconus who referred to the Corneal Clinic of Nikookari Hospital in Tabriz and the controls had no eye diseases. Corneal biomechanics, corneal hysteresis, and corneal resistance factor were evaluated in all the samples using an ocular response analyzer device. Results: The present study was carried out on 213 keratoconus eyes and 179 normal eyes. The mean scores of corneal hysteresis were obtained at 13.49±1.34 and 7.67±1.01 mmHg for normal and keratoconus eyes, respectively, which were significantly different between the two groups. The differences between the corneal hysteresis of mild (8.86 mm Hg), moderate (8.30 mm Hg), and severe (7.10 mm Hg) keratoconus eyes were also significant. The mean scores of the corneal resistance factor were reported as 12.68±1.15 and 7.36±1.07 mmHg for normal and keratoconus eyes, respectively, which were significantly different between the two groups. The differences between the corneal resistance factor of mild (8.55 mm Hg), moderate (8.05 mm Hg), and severe (6.76 mm Hg) keratoconus eyes were also significant. Conclusion: The obtained results of the present study showed that corneal hysteresis and corneal resistance factor were lower in keratoconus eyes, compared to those in normal eyes and decreased with the severity of the disease.
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圆锥角膜患者生物力学特征与病情严重程度的相关性研究
背景与目的:圆锥角膜是一种以不断变薄和突出为特征的角膜疾病,可导致视力缺陷。圆锥角膜病变引起的超声对角膜结构的改变,使其硬度和生物力学性能发生一定的改变。在这方面,本研究旨在确定圆锥角膜患者的生物力学特征与疾病严重程度的相关性。材料与方法:病例组选自大不里士Nikookari医院角膜门诊就诊的圆锥角膜患者,对照组无眼部疾病。使用眼反应分析仪对所有样本的角膜生物力学、角膜迟滞和角膜阻力因子进行评估。结果:对圆锥角膜213只眼和正常眼179只眼进行了观察。正常眼和圆锥角膜眼的平均迟滞评分分别为13.49±1.34和7.67±1.01 mmHg,两组差异有统计学意义。轻度(8.86 mm Hg)、中度(8.30 mm Hg)、重度(7.10 mm Hg)圆锥角膜的角膜迟滞差异也有统计学意义。正常眼和圆锥角膜的角膜阻力因子平均评分分别为12.68±1.15和7.36±1.07 mmHg,两组比较差异有统计学意义。轻度(8.55 mm Hg)、中度(8.05 mm Hg)、重度(6.76 mm Hg)圆锥角膜的角膜阻力因子差异也有统计学意义。结论:本研究结果显示圆锥角膜的角膜迟滞和角膜抵抗因子较正常眼低,且随病情的加重而降低。
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来源期刊
CiteScore
0.30
自引率
0.00%
发文量
16
审稿时长
8 weeks
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