[Co(DTPA)]3− complex in gelatin gel as a highly sensitive shifting NMR/MRI temperature probe

IF 1.7 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-06-15 DOI:10.1007/s10847-022-01151-4
S. P. Babailov
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引用次数: 2

Abstract

The temperature sensitivity of paramagnetic chemical shifts in 1H NMR spectra for the [Co(DTPA)]3− complex in 10% gelatin gel (as a model substrate of human or animal tissues) was studied in detail. The maximum temperature sensitivity of the chemical shifts d(δexp)/dT studied in the gelatin gel of the complex was found to be 0.73 ppm/K (which is about 7% higher than in the previously studied D2O solution of the compound). It turned out that the studied complex is characterized by the highest temperature sensitivity of chemical shifts in the NMR spectra among the complexes of paramagnetic d-elements. Moreover, this complex also shows the highest temperature sensitivity of chemical shifts taking into consideration the half-width of the signal itself (|CT|/W = 0.8 K−1). The [Co(DTPA)]3− complex can be considered as a promising compound for the design of temperature-sensitive NMR probes aimed at determining the local temperature in aqueous media and prospective MRI-assisted disease diagnosis.

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[Co(DTPA)]3−配合物在明胶凝胶中作为高灵敏度位移NMR/MRI温度探针
详细研究了[Co(DTPA)]3−配合物在10%明胶凝胶(作为人体或动物组织的模型底物)中顺磁化学位移的温度敏感性。在明胶凝胶中研究的化学位移d(δexp)/dT的最大温度敏感性为0.73 ppm/K(比之前研究的化合物的D2O溶液高约7%)。结果表明,所研究的配合物在顺磁性d元素配合物中具有最高的核磁共振光谱温度敏感性。此外,考虑到信号本身的半宽度(|CT|/W = 0.8 K−1),该配合物还显示出对化学位移的最高温度灵敏度。[Co(DTPA)]3−配合物可以被认为是设计温度敏感核磁共振探针的一个有前途的化合物,旨在确定水介质中的局部温度和前瞻性mri辅助疾病诊断。
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来源期刊
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Journal of Inclusion Phenomena and Macrocyclic Chemistry Agricultural and Biological Sciences-Food Science
CiteScore
4.10
自引率
8.70%
发文量
54
期刊介绍: The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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