Unexploited Potentials of Endophytic Fungi: Patents Review on Endophytic Fungi Related to Secondary Bioactive Compounds

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-02-22 DOI:10.5530/pres.15.2.023

P. Powar, S. Chaudhari

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Abstract

Endophytic fungi are various micro-organisms that inhabit intracellular or intercellular plant tissues in symbiotic association [at certain stages of their life cycles], without causing damage or morphological changes. The endophytes from medicinal plants are important resources for discovery of natural products and secondary bioactive metabolites having the potential biotechnological applications in agriculture, medicine, and allied sectors. The endophytic fungi such as Acremonium, Aspergillus, Fusarium, Trichoderma, Penicillium, Phomopsis, Pestalotiopsis, Pseudomassari, Quercina, Trichoderma genera have been reported from different medicinal plants with potential therapeutic activity. On the other hand, the endophytic fungi can also confer profound impacts on their host plants like improvement in growth, activation of systemic tolerances towards abiotic/biotic stresses, enhancement of nutrient solublization, biosynthesis of phytohormones and stimulating accumulation of secondary metabolites. Endophytic fungi have attracted much research interest because they have provided not only novel sources of Cytotoxic compounds, Antimicrobial agents, Bio-stimulants for essential oil biosynthesis, Anticancer agents, antioxidant agents, anti-diabetic agents, immunosuppressant and insecticidal compounds. The present review reveals the importance of endophytic fungi from medicinal plants as a source of bioactive compounds as well as landscape of patents related to the production of secondary metabolites through endophytic fungi and their application in pharmaceutical sectors.

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内生真菌未开发的潜力:与次生生物活性化合物相关的内生真菌专利综述

内生真菌是栖息在细胞内或细胞间植物组织中的各种微生物，[在其生命周期的某些阶段]以共生关系存在，不会造成损害或形态改变。药用植物内生菌是发现天然产物和次生生物活性代谢物的重要资源，在农业、医药等相关领域具有潜在的生物技术应用前景。从不同的药用植物中发现了具有潜在治疗活性的内生真菌，如Acremonium、Aspergillus、Fusarium、Trichoderma、Penicillium、Phomopsis、Pestalotiopsis、Pseudomassari、Quercina、Trichoderma等。另一方面，内生真菌也可以对寄主植物产生深远的影响，如改善生长，激活对非生物/生物胁迫的系统耐受性，增强养分溶解，植物激素的生物合成和刺激次生代谢物的积累。内生真菌不仅为细胞毒性化合物、抗菌剂、精油生物合成的生物刺激剂、抗癌剂、抗氧化剂、抗糖尿病剂、免疫抑制剂和杀虫化合物提供了新的来源，而且引起了人们的广泛关注。本文综述了药用植物内生真菌作为生物活性化合物来源的重要性，以及通过内生真菌生产次生代谢物的专利概况及其在制药领域的应用。

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来源期刊

Pharmacognosy Research PHARMACOLOGY & PHARMACY-

自引率

14.30%

发文量

期刊介绍： Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.