Predictors of Thyroid Gland Invasion in Total Laryngectomy for Advanced Laryngeal Squamous Cell Carcinoma.

IF 1 4区医学 Q3 OTORHINOLARYNGOLOGY Ent-Ear Nose & Throat Journal Pub Date : 2025-03-01 Epub Date: 2022-05-09 DOI:10.1177/01455613221098300

Jiaxuan Xie, Hui Liu, Peiyan Wu, Liangsi Chen, Pingjiang Ge, Shaohua Chen, Siyi Zhang, Zhongming Lu

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Abstract

Objectives: Thyroidectomy for advanced laryngeal squamous cell carcinoma (LSCC) is controversial. This study aimed to identify predictors of thyroid gland invasion in patients with LSCC and management of the thyroid gland during total laryngectomy. Patients and Methods: Clinical data and pathological characteristics of 113 patients, who underwent laryngectomy with thyroidectomy for advanced LSCC in Guangdong Provincial People's Hospital between 2009 and 2019, were retrospectively analyzed. The incidence and predictors of thyroid gland invasion were analyzed, and a new predictor was proposed using a parallel test. Results: Of 113 patients, 25.7% exhibited thyroid invasion. A new predictor that combined the lower third of thyroid cartilage invasion and thyroid gland invasion on computed tomography/magnetic resonance imaging (CT/MRI) was associated with pathological thyroid gland invasion (P = 0.001; sensitivity, 88.2%; negative predictive value, 95%). Conclusion: Thyroidectomy may be required during total laryngectomy in those with invasion of the lower third of thyroid cartilage and/or thyroid gland invasion revealed on CT/MRI instead of being performed routinely.

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晚期喉鳞状细胞癌全喉切除术中甲状腺侵袭的预测因素。

目的：甲状腺切除术治疗晚期喉鳞状细胞癌是有争议的。本研究旨在确定LSCC患者甲状腺侵犯的预测因素以及全喉切除术期间甲状腺的管理。患者与方法：回顾性分析广东省人民医院2009年至2019年收治的113例晚期喉鳞癌患者的临床资料和病理特征。分析了甲状腺侵犯的发生率和预测因素，并利用平行检验提出了一种新的预测因素。结果：113例患者中，25.7%表现为甲状腺侵犯。在计算机断层扫描/磁共振成像（CT/MRI）上，一项新的预测指标结合了甲状腺软骨侵袭和甲状腺侵袭的下三分之一，与病理性甲状腺侵袭相关（P=0.001；敏感性，88.2%；阴性预测值，95%）。结论：对于CT/MRI显示有甲状腺下三分之一软骨侵犯和/或甲状腺侵犯的患者，在全喉切除术期间可能需要进行甲状腺切除术，而不是常规进行。

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来源期刊

Ent-Ear Nose & Throat Journal 医学-耳鼻喉科学

CiteScore

3.20

自引率

0.00%

发文量

385

审稿时长

6-12 weeks

期刊介绍： Ear, Nose & Throat Journal provides practical, peer-reviewed original clinical articles, highlighting scientific research relevant to clinical care, and case reports that describe unusual entities or innovative approaches to treatment and case management. ENT Journal utilizes multiple channels to deliver authoritative and timely content that informs, engages, and shapes the industry now and into the future.